A redox-based mechanism for cardioprotection induced by ischemic preconditioning in perfused rat heart

W Chen, S Gabel, C Steenbergen, E Murphy - Circulation research, 1995 - Am Heart Assoc
Recent studies have suggested that mild redox alterations can regulate cell function.
Therefore, we tested the hypothesis that alteration in the thiol redox state might be …

Preconditioning protects ischemic rabbit heart by protein kinase C activation

K Ytrehus, Y Liu, JM Downey - American Journal of …, 1994 - journals.physiology.org
Myocardial protection in the rabbit induced by ischemic preconditioning is thought to be
adenosine receptor linked, but the signaling pathway responsible for the protection has yet …

[HTML][HTML] Cardiac preconditioning with calcium: clinically accessible myocardial protection

DR Meldrum, JC Cleveland Jr, BC Sheridan… - The Journal of Thoracic …, 1996 - Elsevier
Cardiac preconditioning is mediated by protein kinase C. Although endogenous calcium is a
potent stimulus of protein kinase C, it remains unknown whether preischemic administration …

Cardiac preconditioning with 4-h, 17°C ischemia reduces [Ca2+]i load and damage in part via KATP channel opening

Q Chen, AKS Camara, J An, ML Riess… - American Journal …, 2002 - journals.physiology.org
Brief ischemia before normothermic ischemia protects hearts against reperfusion injury
(ischemic preconditioning, IPC), but it is unclear whether it protects against long-term …

Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning

CM Cao, Q Xia, Q Gao, M Chen, TM Wong - Journal of Pharmacology and …, 2005 - ASPET
We tested the hypothesis that the high-conductance calciumactivated potassium (KCa)
channel is involved in the cardioprotection of preconditioning with ischemic insults. In the …

Inhibition of Sarcolemmal Na+,K+-ATPase Activity Reduces the Infarct Size–Limiting Effect of Preconditioning in Rabbit Hearts

R Nawada, T Murakami, T Iwase, K Nagai, Y Morita… - Circulation, 1997 - Am Heart Assoc
Background The inhibition of sarcolemmal Na+, K+-ATPase activity is closely related to
ischemic myocardial cell injury. However, the involvement of this enzyme in preconditioning …

Effect of ischemic preconditioning on mitochondrial oxidative phosphorylation and high energy phosphates in rat hearts

M Kobara, T Tatsumi, S Matoba, Y Yamahara… - Journal of molecular and …, 1996 - Elsevier
The ability of ischemic preconditioning (IP) to protect the myocardium against prolonged
ischemia may derive from improved energy balance. We therefore examined myocardial …

Protein kinase C activation and cardioprotective effect of preconditioning with oxidative stress in isolated rat heart

A Sharma, M Singh - Molecular and Cellular Biochemistry, 2001 - Springer
The present study is designed to investigate the effect of myocardial preconditioning with
oxidative stress induced by pyrogallol or H 2 O 2, on ischaemia-reperfusion induced …

Protein kinase C-ξ is responsible for the protection of preconditioning in rabbit cardiomyocytes

GS Liu, MV Cohen, D Mochly-Rosen… - Journal of molecular and …, 1999 - Elsevier
The role of protein kinase C (PKC) in the protection of ischemic preconditioning (PC) is still
controversial, partly because of the multiple isozymes of PKC and the inability to directly …

Ischemic preconditioning attenuates apoptosis through protein kinase C in rat hearts

T Okamura, T Miura, H Iwamoto… - American Journal …, 1999 - journals.physiology.org
To investigate the role of protein kinase C (PKC) in the mechanism of ischemic
preconditioning (IP), infarct size and the incidence of apoptosis caused by ischemia …