Mechanism of preconditioning. Ionic alterations.
C Steenbergen, ME Perlman, RE London… - Circulation …, 1993 - Am Heart Assoc
The mechanism by which preconditioning (brief intermittent periods of ischemia and reflow)
improves recovery of function and reduces enzyme release after a subsequent 30-minute …
improves recovery of function and reduces enzyme release after a subsequent 30-minute …
Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K+ Channel? Studies of Contractile Function After Simulated …
ME Speechly-Dick, GJ Grover, DM Yellon - Circulation research, 1995 - Am Heart Assoc
Protein kinase C (PKC) and the ATP-dependent K+ channel (KATP channel) have been
implicated in the mechanism of ischemic preconditioning in animal models. This study …
implicated in the mechanism of ischemic preconditioning in animal models. This study …
Protein kinase C and preconditioning: role of the sarcoplasmic reticulum
K Yamamura, C Steenbergen… - American Journal of …, 2005 - journals.physiology.org
Activation of protein kinase C (PKC) is cardioprotective, but the mechanism (s) by which
PKC mediates protection is not fully understood. Inasmuch as PKC has been well …
PKC mediates protection is not fully understood. Inasmuch as PKC has been well …
Ischemic preconditioning induces selective translocation of protein kinase C isoforms ε and η in the heart of conscious rabbits without subcellular redistribution of total …
P Ping, J Zhang, Y Qiu, XL Tang… - Circulation …, 1997 - Am Heart Assoc
Considerable controversy surrounds the role of protein kinase C (PKC) in ischemic
preconditioning (PC). Previous studies have used pharmacological agents and/or measured …
preconditioning (PC). Previous studies have used pharmacological agents and/or measured …
Importance of metabolic inhibition and cellular pH in mediating preconditioning contractile and metabolic effects in rat hearts.
CP De Albuquerque, G Gerstenblith… - Circulation research, 1994 - Am Heart Assoc
The pathophysiological mechanisms by which brief periods of flow interruption before a
prolonged ischemic period, ischemic preconditioning (IPC), increase myocardial tolerance …
prolonged ischemic period, ischemic preconditioning (IPC), increase myocardial tolerance …
Ischemic preconditioning: from basic mechanisms to clinical applications
A Nakano, MV Cohen, JM Downey - Pharmacology & Therapeutics, 2000 - Elsevier
When the heart is subjected to a transient nonlethal period of ischemia, it quickly adapts
itself to become resistant to infarction from a subsequent ischemic insult. This adaptation is …
itself to become resistant to infarction from a subsequent ischemic insult. This adaptation is …
Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.
RA Gottlieb, DL Gruol, JY Zhu… - The Journal of clinical …, 1996 - Am Soc Clin Investig
Ischemic preconditioning signals through protein kinase C (PKC) to protect against
myocardial infarction. This protection is characterized by diminished intracellular …
myocardial infarction. This protection is characterized by diminished intracellular …
Additive protective effects of late and early ischaemic preconditioning are mediated by the opening of KATP channels in vivo
J Müllenheim, W Schlack, J Frässdorf, A Heinen… - Pflügers Archiv, 2001 - Springer
We investigated whether a combination of ischaemic late preconditioning (LPC) and
ischaemic early preconditioning (EPC) induces additive myocardial protection in vivo, and …
ischaemic early preconditioning (EPC) induces additive myocardial protection in vivo, and …
Ischemic preconditioning targets the reperfusion phase
DJ Hausenloy, AM Wynne, DM Yellon - Basic research in cardiology, 2007 - Springer
Emerging studies suggest that signaling during the myocardial reperfusion phase
contributes to ischemic preconditioning (IPC). Whether the activation of PKC, the opening of …
contributes to ischemic preconditioning (IPC). Whether the activation of PKC, the opening of …
Signal transduction mechanisms involved in cardiac preconditioning: Role of Ras-GTPase, Ca2 +/calmodulin-dependent protein kinase II and epidermal growth …
IF Benter, JS Juggi, I Khan, MHM Yousif… - Molecular and cellular …, 2005 - Springer
It is well established that brief episodes of ischemia/reperfusion (I/R)[preconditioning (PC)]
protect the myocardium from the damage induced by subsequent more prolonged I/R …
protect the myocardium from the damage induced by subsequent more prolonged I/R …