Genes, pathways, and mechanisms involved in the virulence of mucorales

C Lax, C Pérez-Arques, MI Navarro-Mendoza… - Genes, 2020 - mdpi.com
The order Mucorales is a group of ancient fungi with limited tools for gene manipulation. The
main consequence of this manipulation unwillingness is the limited knowledge about its …

Mucorales and Mucormycosis: Recent Insights and Future Prospects

G Tahiri, C Lax, JT Cánovas-Márquez, P Carrillo-Marín… - Journal of Fungi, 2023 - mdpi.com
The classification of Mucorales encompasses a collection of basal fungi that have
traditionally demonstrated an aversion to modern genetic manipulation techniques. This …

Mucorales species and macrophages

FE Nicolás, L Murcia, E Navarro, MI Navarro-Mendoza… - Journal of Fungi, 2020 - mdpi.com
Mucormycosis is an emerging fungal infection caused by Mucorales with an unacceptable
high mortality rate. Mucorales is a complex fungal group, including eleven different genera …

Molecular mechanisms that govern infection and antifungal resistance in Mucorales

C Lax, FE Nicolás, E Navarro… - … and Molecular Biology …, 2024 - Am Soc Microbiol
SUMMARY The World Health Organization has established a fungal priority pathogens list
that includes species critical or highly important to human health. Among them is the order …

A non-canonical RNAi pathway controls virulence and genome stability in Mucorales

C Pérez-Arques, MI Navarro-Mendoza, L Murcia… - PLoS …, 2020 - journals.plos.org
Epimutations in fungal pathogens are emerging as novel phenomena that could explain the
fast-developing resistance to antifungal drugs and other stresses. These epimutations are …

Understanding Mucormycoses in the Age of “omics”

AY Soare, TN Watkins, VM Bruno - Frontiers in Genetics, 2020 - frontiersin.org
Mucormycoses are deadly invasive infections caused by several fungal species belonging
to the subphylum Mucoromycotina, order Mucorales. Hallmarks of disease progression …

RNAi-based functional genomics identifies new virulence determinants in mucormycosis

TA Trieu, MI Navarro-Mendoza, C Pérez-Arques… - PLoS …, 2017 - journals.plos.org
Mucorales are an emerging group of human pathogens that are responsible for the lethal
disease mucormycosis. Unfortunately, functional studies on the genetic factors behind the …

Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors

MIA Hassan, K Voigt - Medical Mycology, 2019 - academic.oup.com
Fungi of the basal lineage order Mucorales are able to cause infections in animals and
humans. Mucormycosis is a well-known, life-threatening disease especially in patients with …

Recent advances in the pathogenesis of mucormycoses

G Petrikkos, C Tsioutis - Clinical Therapeutics, 2018 - Elsevier
Purpose The purposes of this review are to describe the pathogenesis of mucormycosis and
to address recent research advances in understanding the mechanisms of fungal invasion …

The mucormycete–host interface

AS Ibrahim, K Voelz - Current opinion in microbiology, 2017 - Elsevier
Highlights•The innate immune system controls mucormycete spores by inhibiting spore
germination.•There is limited evidence for adaptive immunity in combating …