Epidemiology and genetics of venous thromboembolism and chronic venous disease

RA Baylis, NL Smith, D Klarin, E Fukaya - Circulation research, 2021 - Am Heart Assoc
Venous disease is a term that broadly covers both venous thromboembolic disease and
chronic venous disease. The basic pathophysiology of venous thromboembolism and …

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

D Klarin, E Busenkell, R Judy, J Lynch, M Levin… - Nature …, 2019 - nature.com
Venous thromboembolism is a significant cause of mortality, yet its genetic determinants are
incompletely defined. We performed a discovery genome-wide association study in the …

Environmental and genetic risk factors associated with venous thromboembolism

M Crous-Bou, LB Harrington… - Seminars in thrombosis …, 2016 - thieme-connect.com
Venous thromboembolism (VTE) includes deep vein thrombosis and pulmonary embolism,
and a combination of environmental and genetic risk factors contributes to VTE risk. Within …

Genetics of venous thrombosis: insights from a new genome wide association study

M Germain, N Saut, N Greliche, C Dina, JC Lambert… - PloS one, 2011 - journals.plos.org
Background Venous Thrombosis (VT) is a common multifactorial disease associated with a
major public health burden. Genetics factors are known to contribute to the susceptibility of …

The genetics of venous thromboembolism

R Gohil, G Peck, P Sharma - Thrombosis and haemostasis, 2009 - thieme-connect.com
We conducted a systematic and comprehensive meta-analysis on all candidate genes to
assess their genetic contribution to the aetiology of venous thromboembolism …

Genetics of venous thrombosis: update in 2015

PE Morange, P Suchon… - Thrombosis and …, 2015 - thieme-connect.com
Venous thrombosis (VT) is a common multifactorial disease with a genetic component that
was first suspected nearly 60 years ago. In this review, we document the genetic …

Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism

J Ghouse, V Tragante, G Ahlberg, SA Rand… - Nature …, 2023 - nature.com
We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …

Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

S Lindström, LU Wang, EN Smith… - Blood, The Journal …, 2019 - ashpublications.org
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …

Current knowledge on the genetics of incident venous thrombosis

PE Morange, DA Trégouët - Journal of thrombosis and …, 2013 - Wiley Online Library
The genetic burden underlying venous thrombosis (VT) is characterized by a sibling relative
risk of 2.5 and a strong heritability whose estimates varied from 35% to 60% according to …

[HTML][HTML] A genome‐wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24. 2 and 9q

JA Heit, SM Armasu, YW Asmann… - Journal of thrombosis …, 2012 - Elsevier
Objectives: To identify venous thromboembolism (VTE) disease‐susceptibility genes.
Patients and methods: We performed in silico genome wide association scan (GWAS) …