[HTML][HTML] Regional functional connectivity predicts distinct cognitive impairments in Alzheimer's disease spectrum

KG Ranasinghe, LB Hinkley, AJ Beagle, D Mizuiri… - NeuroImage: Clinical, 2014 - Elsevier
Understanding neural network dysfunction in neurodegenerative disease is imperative to
effectively develop network-modulating therapies. In Alzheimer's disease (AD), cognitive …

Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole‐Brain, Data‐Driven Analysis

B Zhou, H Yao, P Wang, Z Zhang… - BioMed research …, 2015 - Wiley Online Library
The purpose of our study was to investigate whether the whole‐brain functional connectivity
pattern exhibits disease severity‐related alterations in patients with Alzheimer's disease …

Disrupted functional brain connectivity and its association to structural connectivity in amnestic mild cognitive impairment and Alzheimer's disease

Y Sun, Q Yin, R Fang, X Yan, Y Wang, A Bezerianos… - PloS one, 2014 - journals.plos.org
Although anomalies in the topological architecture of whole-brain connectivity have been
found to be associated with Alzheimer's disease (AD), our understanding about the …

Default-Mode Network Connectivity Changes During the Progression Toward Alzheimer's Dementia: A Longitudinal Functional Magnetic Resonance Imaging Study

V Malotaux, L Dricot, L Quenon, R Lhommel… - Brain …, 2023 - liebertpub.com
Background/Purpose: Brain function changes with Alzheimer's disease (AD) progression.
Evaluating those changes longitudinally is important to understand the complex …

Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants

M Lehmann, C Madison, PM Ghosh, ZA Miller… - Neurobiology of …, 2015 - Elsevier
The common and specific involvement of brain networks in clinical variants of Alzheimer's
disease (AD) is not well understood. We performed task-free (“resting-state”) functional …

Longitudinal study of impaired intra-and inter-network brain connectivity in subjects at high risk for Alzheimer's disease

Y Zhan, J Ma, AF Alexander-Bloch, K Xu… - Journal of …, 2016 - content.iospress.com
Alzheimer's disease (AD) is associated with abnormal resting-state network (RSN)
architecture of the default mode network (DMN), the dorsal attention network (DAN), the …

Increased functional connectivity within medial temporal lobe in mild cognitive impairment

SR Das, J Pluta, L Mancuso, D Kliot, S Orozco… - …, 2013 - Wiley Online Library
Pathology at preclinical and prodromal stages of Alzheimer's disease (AD) may manifest
itself as measurable functional change in neuronal networks earlier than detectable …

Differential abnormality in functional connectivity density in preclinical and early-stage Alzheimer's disease

Y Song, H Wu, S Chen, H Ge, Z Yan, C Xue… - Frontiers in Aging …, 2022 - frontiersin.org
Background Both subjective cognitive decline (SCD) and amnestic mild cognitive
impairment (aMCI) have a high risk of progression to Alzheimer's disease (AD). While most …

Functional connectivity and graph theory in preclinical Alzheimer's disease

MR Brier, JB Thomas, AM Fagan, J Hassenstab… - Neurobiology of …, 2014 - Elsevier
Alzheimer's disease (AD) has a long preclinical phase in which amyloid and tau cerebral
pathology accumulate without producing cognitive symptoms. Resting state functional …

Aberrant intra-and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment

P Wang, B Zhou, H Yao, Y Zhan, Z Zhang, Y Cui… - Scientific reports, 2015 - nature.com
Alzheimer's disease (AD) patients and those with high-risk mild cognitive impairment are
increasingly considered to have dysfunction syndromes. Large-scale network studies based …