[HTML][HTML] SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy

X Li, P Hou, W Ma, X Wang, H Wang, Z Yu… - Cellular & molecular …, 2022 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …

[HTML][HTML] SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

H Jiang, H Zhang, Q Meng, J Xie, Y Li… - Cellular & molecular …, 2020 - nature.com
COVID-19 is caused by SARS-CoV-2. 1 As of July 16th, 2020, there were 13,579,581
diagnosed cases and 584,782 deaths attributed to COVID-19 reported globally …

[HTML][HTML] ORF3a-mediated incomplete autophagy facilitates severe acute respiratory syndrome coronavirus-2 replication

Y Qu, X Wang, Y Zhu, W Wang, Y Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for
the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to …

[PDF][PDF] Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

M Hayn, M Hirschenberger, L Koepke, R Nchioua… - Cell reports, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate
immune responses but may still be vulnerable to some. Here, we systematically analyze the …

SARS-CoV-2 ORF9c is a membrane-associated protein that suppresses antiviral responses in cells

A Dominguez Andres, Y Feng, AR Campos, J Yin… - BioRxiv, 2020 - biorxiv.org
Disrupted antiviral immune responses are associated with severe COVID-19, the disease
caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of …

[PDF][PDF] SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

J Wu, Y Shi, X Pan, S Wu, R Hou, Y Zhang, T Zhong… - Cell reports, 2021 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a current global health threat caused by
the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

JY Li, CH Liao, Q Wang, YJ Tan, R Luo, Y Qiu, XY Ge - Virus research, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human
coronavirus causing the pandemic of severe pneumonia (Coronavirus Disease 2019 …

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication

P Hou, X Wang, H Wang, T Wang, Z Yu, C Xu, Y Zhao… - Autophagy, 2023 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely related
to various cellular aspects associated with autophagy. However, how SARS-CoV-2 …

SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling …

L Han, MW Zhuang, J Deng, Y Zheng… - Journal of medical …, 2021 - Wiley Online Library
The suppression of types I and III interferon (IFN) responses by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) contributes to the pathogenesis of coronavirus …

[HTML][HTML] Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response

Z Cao, H Xia, R Rajsbaum, X Xia, H Wang… - Cellular & molecular …, 2021 - nature.com
Understanding interactions between the host and SARS-CoV-2 is essential for developing
effective vaccines and therapeutics. Here, we report that SARS-CoV-2 usurps the host …