Maintenance of proper “labile iron” levels is a critical component in preserving homeostasis.
Iron is a vital element that is a constituent of a number of important macromolecules …

Iron is a crucial factor for life. However, it also has the potential to cause the formation of
noxious free radicals. These double-edged sword characteristics demand a tight regulation …

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory
mechanisms have evolved to maintain iron homeostasis within cells and between different …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Iron is needed by all mammalian cells but is toxic in excess. Specialized transport
mechanisms conduct iron across cellular membranes. These are regulated to ensure …

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron
cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc …

In the theater of cellular life, iron plays an ambiguous and yet undoubted lead role. Iron is a
ubiquitous core element of the earth and plays a central role in countless biochemical …

Mammalian iron homeostasis must be meticulously regulated so that this essential element
is available for use, but at the same time prevented from promoting the formation of toxic …

Iron is an essential nutrient, but its concentration and distribution in the body must be tightly
controlled due to its inherent toxicity and insolubility in aqueous solution. Living systems …

Iron is an essential trace element in the human body, but excess iron is toxic as it contributes
to oxidative damage. To keep iron concentration within the optimal physiologic range, iron …