The antileishmanial and antimalarial activity of methoxy-substituted chalcones (1, 3-diphenyl-
2-propen-1-ones) is well established. The few analogs prepared to date where the 3-phenyl …

A series of oxygenated chalcones which have been evaluated earlier for antimalarial activity
(Plasmodium falciparum K1) were tested for antileishmanial activity against Leishmania …

Leishmaniases are endemic diseases in tropical and sub-tropical regions of the world and
are considered by the World Health Organization (WHO) to be among the six most important …

Eighteen analogues of an active natural chalcone were synthesized using xanthoxyline and
some derivatives, and these analogues were tested for selective activity against both …

Several new chalcone analogues were synthesized and evaluated as inhibitors of malaria
parasite. Inhibitory activity was determined in vitro against a chloroquine-sensitive …

Antileishmanial activities of thirty-five synthetic chalcones have been examined. Among
them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity …

A series of novel chalconoids containing a 6-chloro-2H-chromen-3-yl group were prepared
through a convenient and efficient synthetic method by using 5-chloro-2 …

The available drugs for treating Leishmaniasis and American trypanosomiasis have high
toxicity and multiple side effects, among other problems. More effective and less toxic …

A series of chalcones and their derivatives have been synthesized and identified as novel
potential antimalarials using both molecular modelingand in vitro testing against the intact …

Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal
agents. All tested compounds caused concentration-dependent inhibition of the in vitro …