Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications

S Dutta, A Mukherjee, U Nongthomba - Cytokine & Growth Factor Reviews, 2022 - Elsevier
Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is
responsible for the ongoing COVID-19 pandemic, and causes many health complications …

Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

ACG Salina, D Dos-Santos, TS Rodrigues… - Elife, 2022 - elifesciences.org
COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering
immunopathogenesis are not established. The functional plasticity of macrophages allows …

Importance of Efferocytosis in COVID-19 Mortality

A Erol - Infection and Drug Resistance, 2022 - Taylor & Francis
COVID-19 is a generally benign coronavirus disease that can spread rapidly, except for
those with a group of risk factors. Since the pathogenesis responsible for the severity of the …

[HTML][HTML] The lung macrophage in SARS-CoV-2 infection: a friend or a foe?

Z Abassi, Y Knaney, T Karram, SN Heyman - Frontiers in Immunology, 2020 - frontiersin.org
Respiratory, circulatory, and renal failure are among the gravest features of COVID-19 and
are associated with a very high mortality rate. A common denominator of all affected organs …

Monocytes and macrophages in COVID-19: Friends and foes

S Meidaninikjeh, N Sabouni, HZ Marzouni, S Bengar… - Life sciences, 2021 - Elsevier
The COVID-19 is a novel infectious disease caused by SARS-CoV-2 and is known as a
pandemic emergency that has led to a high rate of mortality throughout the world. Evidence …

SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4

F Onodi, L Bonnet-Madin, L Meertens, L Karpf… - Journal of Experimental …, 2021 - rupress.org
Several studies have analyzed antiviral immune pathways in late-stage severe COVID-19.
However, the initial steps of SARS-CoV-2 antiviral immunity are poorly understood. Here we …

SARS-CoV-2 dysregulates neutrophil degranulation and reduces lymphocyte counts

A Muralidharan, TA Wyatt, SP Reid - Biomedicines, 2022 - mdpi.com
SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest
pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been …

Pulmonary macrophages and SARS-Cov2 infection

CC Bain, AG Rossi, CD Lucas - International Review of Cell and Molecular …, 2022 - Elsevier
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led
to the largest global pandemic in living memory, with between 4.5 and 15M deaths globally …

[HTML][HTML] Monocytes and Macrophages in COVID-19

R Knoll, JL Schultze, J Schulte-Schrepping - Frontiers in immunology, 2021 - frontiersin.org
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …

Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation

O García-Nicolás, A Godel, G Zimmer… - Cellular & molecular …, 2023 - nature.com
Early and strong interferon type I (IFN-I) responses are usually associated with mild COVID-
19 disease, whereas persistent or unregulated proinflammatory cytokine responses are …