The role of macrophages in the pathogenesis of SARS-CoV-2-associated acute respiratory distress syndrome

A Kosyreva, D Dzhalilova, A Lokhonina… - Frontiers in …, 2021 - frontiersin.org
Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a
major role in both physiological and pathological processes. Systemic SARS-CoV-2 …

SARS-CoV 2; Possible alternative virus receptors and pathophysiological determinants

L Pruimboom - Medical Hypotheses, 2021 - Elsevier
Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
highjacks epithelial cells and infiltrates the lung, as well as other organs and tissues, is …

A bird's eye view on the role of dendritic cells in SARS‐CoV‐2 infection: Perspectives for immune‐based vaccines

D Galati, S Zanotta, L Capitelli, M Bocchino - Allergy, 2022 - Wiley Online Library
Abstract Coronavirus disease‐19 (COVID‐19) is a complex disorder caused by the
pandemic diffusion of a novel coronavirus named SARS‐CoV‐2. Clinical manifestations …

Cell death in coronavirus infections: Uncovering its role during COVID-19

A Paolini, R Borella, S De Biasi, A Neroni, M Mattioli… - Cells, 2021 - mdpi.com
Cell death mechanisms are crucial to maintain an appropriate environment for the
functionality of healthy cells. However, during viral infections, dysregulation of these …

Alveolar macrophages: Achilles' heel of SARS-CoV-2 infection

Z Wang, S Li, B Huang - Signal Transduction and Targeted Therapy, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused more than 6.3
million deaths to date. Despite great efforts to curb the spread of severe acute respiratory …

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
Abstract The COVID-19-, SARS-and MERS-related coronaviruses share many genomic and
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …

SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

IS Mahmoud, YB Jarrar, W Alshaer, S Ismail - Biochimie, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that
has gained global attention owing to its ability to provoke community and health-care …

Interplay between Neutrophils, NETs and T-Cells in SARS-CoV-2 Infection—A Missing Piece of the Puzzle in the COVID-19 Pathogenesis?

P Niedźwiedzka-Rystwej, E Grywalska, R Hrynkiewicz… - Cells, 2021 - mdpi.com
Since the end of 2019, a new, dangerous virus has caused the deaths of more than 3 million
people. Efforts to fight the disease remain multifaceted and include prophylactic strategies …

Central role of lung macrophages in SARS-CoV-2 physiopathology: a cross-model single-cell RNA-seq perspective

T Olivier, J Blomet, D Desmecht - Frontiers in Immunology, 2023 - frontiersin.org
Cytokine storms are considered a driving factor in coronavirus disease 2019 (COVID-19)
severity. However, the triggering and resolution of this cytokine production, as well as the …

The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)

A Arcanjo, J Logullo, CCB Menezes… - Scientific reports, 2020 - nature.com
The novel coronavirus SARS-CoV-2 causes COVID-19, a highly pathogenic viral infection
threatening millions. The majority of the individuals infected are asymptomatic or mildly …