[HTML][HTML] Macrophages and dendritic cells are not the major source of pro-inflammatory cytokines upon SARS-CoV-2 infection

MA Niles, P Gogesch, S Kronhart… - Frontiers in …, 2021 - frontiersin.org
The exact role of innate immune cells upon infection with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and their contribution to the formation of the corona virus …

[HTML][HTML] Monocytes and macrophages in severe COVID‐19–friend, foe or both?

RJ Dress, F Ginhoux - Immunology and Cell Biology, 2021 - ncbi.nlm.nih.gov
While most COVID-19 patients have mild symptoms, about 15% of patients develop severe
COVID-19 often with fatal outcomes, and scientists have been on the hunt to understand the …

[HTML][HTML] ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response

C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen… - Cell stem cell, 2021 - cell.com
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …

[HTML][HTML] Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression

G Schönrich, MJ Raftery, Y Samstag - Advances in biological regulation, 2020 - Elsevier
Abstract Pandemic coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses an unprecedented challenge …

[HTML][HTML] NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 …

I Tsukalov, I Sánchez-Cerrillo, O Rajas… - Nature …, 2024 - nature.com
Increased recruitment of transitional and non-classical monocytes in the lung during SARS-
CoV-2 infection is associated with COVID-19 severity. However, whether specific innate …

[HTML][HTML] Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19

FR Hopkins, M Govender, C Svanberg… - Frontiers in …, 2023 - frontiersin.org
Introduction After more than two years the Coronavirus disease-19 (COVID-19) pandemic
continues to burden healthcare systems and economies worldwide, and it is evident that the …

Peripheral innate and adaptive immune cells during COVID‐19: Functional neutrophils, pro‐inflammatory monocytes, and half‐dead lymphocytes

E Ekşioğlu‐Demiralp, S Alan, U Sili… - Cytometry Part B …, 2022 - Wiley Online Library
Background A better understanding of innate and adaptive cells in COVID‐19 is necessary
for the development of effective treatment methods and vaccines. Methods We studied …

[HTML][HTML] SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

[HTML][HTML] Modulation of host immune response is an alternative strategy to combat SARS-CoV-2 pathogenesis

L Singh, S Bajaj, M Gadewar, N Verma… - Frontiers in …, 2021 - frontiersin.org
The novel SARS-CoV-2virus that caused the disease COVID-19 is currently a pandemic
worldwide. The virus requires an alveolar type-2 pneumocyte in the host to initiate its life …

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 …