Peripheral innate and adaptive immune cells during COVID‐19: Functional neutrophils, pro‐inflammatory monocytes, and half‐dead lymphocytes

E Ekşioğlu‐Demiralp, S Alan, U Sili… - Cytometry Part B …, 2022 - Wiley Online Library
Background A better understanding of innate and adaptive cells in COVID‐19 is necessary
for the development of effective treatment methods and vaccines. Methods We studied …

[HTML][HTML] Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19

DM Kim, Y Kim, JW Seo, J Lee, U Park, NY Ha, J Koh… - Cell reports, 2021 - cell.com
Despite the worldwide effect of the coronavirus disease 2019 (COVID-19) pandemic, the
underlying mechanisms of fatal viral pneumonia remain elusive. Here, we show that critical …

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 …

[HTML][HTML] Understanding the immunopathogenesis of COVID-19: Its implication for therapeutic strategy

Y Shimizu - World journal of clinical cases, 2020 - ncbi.nlm.nih.gov
Although 80% of individuals infected with the severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2) recover without antiviral treatments, the other 20% progress to …

Mechanisms underlying potential therapeutic approaches for COVID-19

A Benani, S Ben Mkaddem - Frontiers in Immunology, 2020 - frontiersin.org
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), which is a betacoronavirus, and is associated with cytokine …

Modulation of host immune response is an alternative strategy to combat SARS-CoV-2 pathogenesis

L Singh, S Bajaj, M Gadewar, N Verma… - Frontiers in …, 2021 - frontiersin.org
The novel SARS-CoV-2virus that caused the disease COVID-19 is currently a pandemic
worldwide. The virus requires an alveolar type-2 pneumocyte in the host to initiate its life …

Suppressive myeloid cells are a hallmark of severe COVID-19

J Schulte-Schrepping, N Reusch, D Paclik, K Baßler… - MedRxiv, 2020 - medrxiv.org
Abstract 'Severe Acute Respiratory Syndrome-Coronavirus-2'(SARS-CoV-2) infection
causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract infection …

Single-cell analysis reveals cell communication triggered by macrophages associated with the reduction and exhaustion of CD8+ T cells in COVID-19

L He, Q Zhang, Y Zhang, Y Fan, F Yuan, S Li - Cell Communication and …, 2021 - Springer
Background The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute
respiratory syndrome coronavirus 2 (SARS-Cov-2) has become an ongoing pandemic …

Novel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients

S Qin, X Yao, W Li, C Wang, W Xu, Z Gan, Y Yang… - Cell Death & …, 2023 - nature.com
How does SARS-CoV-2 cause lung microenvironment disturbance and inflammatory storm
is still obscure. We here performed the single-cell transcriptome sequencing from lung …

The amount of cytokine-release defines different shades of Sars-Cov2 infection

S Bindoli, M Felicetti, P Sfriso… - … Biology and Medicine, 2020 - journals.sagepub.com
The recent outbreak of coronavirus disease (COVID 19), spreading from China all around
the world in early 2020, has led scientists to investigate the immuno-mediated mechanisms …