Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E−/-mice

M Kim, A Sahu, Y Hwang, GB Kim, GH Nam, IS Kim… - Biomaterials, 2020 - Elsevier
Unresolved inflammation is a hallmark of many deadly diseases including atherosclerosis, a
silent pathological condition behind majority of cardiovascular diseases. Yet, anti …

CD47‐ and Integrin α4/β1‐Comodified‐Macrophage‐Membrane‐Coated Nanoparticles Enable Delivery of Colchicine to Atherosclerotic Plaque

Y Li, J Che, L Chang, M Guo, X Bao… - Advanced …, 2022 - Wiley Online Library
Atherosclerosis is a chronic inflammatory disease and the major pathological factor of most
cardiovascular diseases, leading to≈ 1/3 of deaths worldwide. Improving local delivery of …

Targeted interleukin-10 nanotherapeutics developed with a microfluidic chip enhance resolution of inflammation in advanced atherosclerosis

N Kamaly, G Fredman, JJR Fojas, M Subramanian… - ACS …, 2016 - ACS Publications
Inflammation is an essential protective biological response involving a coordinated cascade
of signals between cytokines and immune signaling molecules that facilitate return to tissue …

[HTML][HTML] Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease

T Matoba, J Koga, K Nakano, K Egashira, H Tsutsui - Journal of cardiology, 2017 - Elsevier
Administration of drugs and other therapeutic agents has been the central strategy of
contemporary medicine for cardiovascular disease. The use of drug delivery systems (DDS) …

[HTML][HTML] Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

C Gao, Q Huang, C Liu, CHT Kwong, L Yue… - Nature …, 2020 - nature.com
Vascular disease remains the leading cause of death and disability, the etiology of which
often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy …

Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis

Y Dou, Y Chen, X Zhang, X Xu, Y Chen, J Guo… - Biomaterials, 2017 - Elsevier
Atherosclerosis is the leading cause of many fatal cardiovascular and cerebrovascular
diseases. Whereas nanomedicines are promising for targeted therapy of atherosclerosis …

[HTML][HTML] Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage …

J He, W Zhang, X Zhou, F Xu, J Zou, Q Zhang, Y Zhao… - Bioactive Materials, 2023 - Elsevier
Nanoparticle-based therapeutics represent potential strategies for treating atherosclerosis;
however, the complex plaque microenvironment poses a barrier for nanoparticles to target …

Plaque macrophage‐targeting nanosystems with cooperative Co‐regulation of ROS and TRAF6 for stabilization of atherosclerotic plaques

Q Yang, H Jiang, Y Wang, X Leng… - Advanced Functional …, 2023 - Wiley Online Library
Chronic inflammatory microenvironment is the predominant milieu that promotes the
progression of atherosclerosis (AS). However, targeted regulation of the chronic …

Biomimetic macrophage membrane and lipidated peptide hybrid nanovesicles for atherosclerosis therapy

L Guo, Y Miao, Y Wang, Y Zhang… - Advanced Functional …, 2022 - Wiley Online Library
Atherosclerosis is the underlying cause for cardiovascular disease. Current
pharmacotherapies are limited by the inadequate targeting and insufficient treatment …

A metal-organic framework-based immunomodulatory nanoplatform for anti-atherosclerosis treatment

Z Xu, Z Wu, S Huang, K Ye, Y Jiang, J Liu, J Liu… - Journal of Controlled …, 2023 - Elsevier
Immunomodulatory therapy has become a promising method for the clinical treatment of
many diseases. Recently, pilot studies revealed that immunomodulatory therapy exhibited …