PPAR-γ: therapeutic prospects in Parkinson's disease

AR Carta - Current drug targets, 2013 - ingentaconnect.com
Parkinson's disease (PD) is amongst the most frequent neurodegenerative disorders, the
main pathologic hallmark of which is the degeneration of the substantia nigra pars …

Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a …

AR Carta, L Frau, A Pisanu, J Wardas, S Spiga… - Neuroscience, 2011 - Elsevier
Thiazolidinedione (TZD) class of peroxisome proliferator receptor gamma (PPAR-γ) agonists
display neuroprotective effects in experimental Parkinson's disease (PD) models. Neurons …

Neuroprotective and anti-inflammatory effects of pioglitazone on Parkinson's disease: A comprehensive narrative review of clinical and experimental findings

MY Zamanian, EM Terefe, N Taheri… - CNS & Neurological …, 2023 - ingentaconnect.com
Parkinson's disease (PD) is a chronic and progressive neurological disorder characterized
by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) …

PPAR: a therapeutic target in Parkinson's disease

RK Chaturvedi, MF Beal - Journal of neurochemistry, 2008 - Wiley Online Library
Parkinson's disease (PD) is a progressive and chronic neurodegenerative disorder,
characterized by progressive loss of dopaminergic neurons in substantia nigra. The etiology …

PPARγ and PGC-1α as therapeutic targets in Parkinson's

JC Corona, MR Duchen - Neurochemical research, 2015 - Springer
The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated
transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was …

PPAR‐gamma‐mediated neuroprotection in a chronic mouse model of Parkinson's disease

N Schintu, L Frau, M Ibba, P Caboni… - European Journal of …, 2009 - Wiley Online Library
Rosiglitazone is a commonly prescribed insulin‐sensitizing drug with a selective agonistic
activity on the peroxisome proliferator‐activated receptor‐gamma (PPAR‐γ). PPAR‐γ can …

Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?

AR Carta, A Pisanu - Neurotoxicity research, 2013 - Springer
A dysregulated response of the neuroimmune system is a main contributor to the
progression of neurodegeneration in Parkinson's disease (PD). Recent findings suggest that …

Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPARγ agonist in vitro and in MPTP-treated mice

D Lecca, DK Nevin, G Mulas, MA Casu, A Diana… - Neuroscience, 2015 - Elsevier
Peroxisome proliferator-activated receptor (PPAR) γ is a potential pharmacological target for
disease-modification in Parkinson's disease (PD), mainly acting by modulating the …

[HTML][HTML] Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's …

HL Martin, RB Mounsey, S Mustafa, K Sathe… - Experimental …, 2012 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been shown to provide
neuroprotection in a number of neurodegenerative diseases including Parkinson's disease …

Minutes of PPAR-γ agonism and neuroprotection

BRP Kumar, AP Kumar, JA Jose, P Prabitha… - Neurochemistry …, 2020 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPAR-γ) is one of the ligand-activated
transcription factors which regulates a number of central events and considered as a …