Memory effects and Lévy walk dynamics in intracellular transport of cargoes

S Fedotov, N Korabel, TA Waigh, D Han, VJ Allan - Physical Review E, 2018 - APS
We demonstrate the phenomenon of cumulative inertia in intracellular transport involving
multiple motor proteins in human epithelial cells by measuring the empirical survival …

Motility states in bidirectional cargo transport

S Klein, C Appert-Rolland, L Santen - Europhysics Letters, 2015 - iopscience.iop.org
Intracellular cargos which are transported by molecular motors move stochastically along
cytoskeleton filaments. In particular for bidirectionally transported cargos it is an open …

Non-Markovian intracellular transport with sub-diffusion and run-length dependent detachment rate

N Korabel, TA Waigh, S Fedotov, VJ Allan - PloS one, 2018 - journals.plos.org
Intracellular transport of organelles is fundamental to cell function and health. The mounting
evidence suggests that this transport is in fact anomalous. However, the reasons for the …

Motility states of molecular motors engaged in a stochastic tug-of-war

MJI Müller, S Klumpp, R Lipowsky - Journal of Statistical Physics, 2008 - Springer
Intracellular transport is mediated by molecular motors that pull cargos along cytoskeletal
filaments. Many cargos move bidirectionally and are transported by two teams of motors …

Environmental control of microtubule-based bidirectional cargo transport

S Klein, C Appert-Rolland, L Santen - Europhysics Letters, 2014 - iopscience.iop.org
Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the
motors involved generally have opposite pulling directions, and the resulting cargo …

Models for microtubule cargo transport coupling the Langevin equation to stochastic stepping motor dynamics: caring about fluctuations

S Bouzat - Physical Review E, 2016 - APS
One-dimensional models coupling a Langevin equation for the cargo position to stochastic
stepping dynamics for the motors constitute a relevant framework for analyzing multiple …

Molecular motors pulling cargos in the viscoelastic cytosol: how power strokes beat subdiffusion

I Goychuk, VO Kharchenko, R Metzler - Physical Chemistry Chemical …, 2014 - pubs.rsc.org
The discovery of anomalous diffusion of larger biopolymers and submicron tracers such as
endogenous granules, organelles, or virus capsids in living cells, attributed to the …

Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo

S Huda, B Weigelin, K Wolf, KV Tretiakov… - Nature …, 2018 - nature.com
Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of
molecular composition and genetics, but also by the very strategy they employ for …

Anomalous diffusion due to hindering by mobile obstacles undergoing Brownian motion or Orstein-Ulhenbeck processes

H Berry, H Chaté - Physical Review E, 2014 - APS
In vivo measurements of the passive movements of biomolecules or vesicles in cells
consistently report “anomalous diffusion,” where mean-squared displacements scale as a …

Random intermittent search and the tug-of-war model of motor-driven transport

J Newby, PC Bressloff - Journal of Statistical Mechanics: Theory …, 2010 - iopscience.iop.org
We formulate the'tug-of-war'model of microtubule cargo transport by multiple molecular
motors as an intermittent random search for a hidden target. A motor complex consisting of …