Several relations between cytokines and pathogenesis of diabetes are reviewed. In type 1
and type 2 diabetes an increased synthesis is observed and as well as the release of pro …

Insulin-dependent diabetes mellitus (IDDM) is a disease that results from autoimmune
destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. The …

Type 1 diabetes is an autoimmune disease leading to extensive destruction of the
pancreatic β-cells. Our research focusses on the role of β-cells during the course of the …

Cytokines may be important mediators of β-cell damage in early insulin-dependent diabetes
mellitus. In order to further characterize the mechanism (s) of action of cytokines on insulin …

Pro-inflammatory cytokines cause b-cell dysfunction and death. The aim of this study was to
investigate the interactions between different pro-and anti-inflammatory cytokines and their …

Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or
relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to …

Islets of patients with type 2 diabetes display the typical features of an inflammatory process
characterized by the presence of cytokines, chemokines, immune cell infiltration, impaired …

Characterized as a metabolic syndrome with multiple consequences for the lives of patients,
diabetes mellitus is also classified as a chronic non-communicable disease of great scope in …

Considerable efforts have been invested to understand the mechanisms by which pro-
inflammatory cytokines mediate the demise of β-cells in type 1 diabetes but much less …

Insulin-dependent diabetes mellitus is an autoimmune disease characterized by the
selective destruction of the pancreatic β-cell. The autoimmune response that is ultimately …