In recent years, the role of the inflammatory system in the pathogenesis of diabetes has
been increasingly investigated. Cytokines, a group of proteins that are expressed by several …

In pancreatic islets, nitric oxide (NO) produced on exposure to cytokines mediates β-cell
injury leading to diabetes mellitus. On the other hand, l-arginine-derived NO may participate …

The discovery 30 years ago that inflammatory cytokines cause a concentration, activity, and
time-dependent bimodal response in pancreatic β-cell function and viability has been a …

The aim of this paper is to review the information on type 1 and type 2 diabetes with
emphasis on its etiology, pathogenesis and pathophysiology via literature review. Diabetes …

Population‐based studies have shown strong relationship between inflammatory markers
and metabolic disturbances, obesity, and atherosclerosis, whereas inflammation has been …

Abstract Aims Type 2 diabetes (T2D) is a global health problem that will be diagnosed in
almost 300 million people by 2025 according to the World Health Organization. Before being …

Apoptosis of pancreatic β‐cells is the final step in the development of type 1 diabetes (T1D),
leading to critically diminished β‐cell mass and contributing to the onset of hyperglycaemia …

Type 2 diabetes mellitus (T2DM) is characterized by progressive β‐cell dysfunctioning and
insulin resistance. This article reviews recent literature with special focus on inflammatory …

Pancreatic b-cell homeostasis is a balance between programmed cell death (apoptosis) and
regeneration. Although autoimmune diabetes mellitus type 1 (DM1) is the most-studied …

Aims/hypothesis IL-1β and TNF-α contribute to pancreatic beta cell death in type 1 diabetes.
Both cytokines activate the transcription factor nuclear factor-κB (NF-κB), but recent …