Insulin-dependent diabetes mellitus is an autoimmune disease characterized by the
selective destruction of insulin-secreting β cells found in islets of Langerhans. The …

Macrophages are innate immune cells derived from monocytes, which, in turn, arise from
myeloid precursor cells in the bone marrow. Macrophages have many important roles in the …

Type I diabetes mellitus is an autoimmune disease characterized by the selective
destruction of the insulin-secreting β-cell found in pancreatic islets of Langerhans. Cytokines …

The pathogenesis of type 1 diabetes is not clearly understood, but it is generally accepted
that type 1 diabetes is an immune-mediated disease caused by inflammation in the islets of …

The IDDM (LEW. 1AR1/Ztm-iddm) rat is a type 1 diabetic animal model characterized by a
rapid apoptotic pancreatic β-cell destruction. Here we have analyzed the time course of islet …

Type 2 diabetes mellitus results from the complex association of insulin resistance and
pancreatic β-cell failure. Obesity is the main risk factor for type 2 diabetes mellitus, and …

Inflammation plays an important role in the destruction of pancreatic islet β-cells that leads to
type I diabetes. This involves infiltration of T-cells and macrophages into the islets and local …

Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …

Aims/hypothesis Type 1A diabetes results from autoimmune destruction of pancreatic beta
cells. We examined the involvement of TNF-α and IL-1β, as well as of T cells, macrophages …

Inflammation is defined as a cascade of phenomena induced in response to different
pathological stimuli. This physiological occurrence that allows the restoration of homeostasis …