Photoredox-catalyzed intermolecular hydroalkylative dearomatization of electron-deficient indole derivatives

XL Huang, YZ Cheng, X Zhang, SL You - Organic Letters, 2020 - ACS Publications
Dearomatization of indole derivatives offers a straightforward approach to access diverse
indolines. To date, the corresponding dearomative transformations involving electron …

Dearomatization through Photoredox Hydroarylation: Discovery of a Radical-Polar Crossover Strategy

KA McDaniel, NT Jui - Organic letters, 2021 - ACS Publications
Indole dearomatization has been achieved via radical hydroarylation. Under mild
photoredox conditions, a range of indole derivatives undergo hydroarylation to form 2 …

Visible-light induced divergent dearomatization of indole derivatives: controlled access to cyclobutane-fused polycycles and 2-substituted indolines

W Zhuang, YZ Cheng, XL Huang, Q Huang… - Organic Chemistry …, 2021 - pubs.rsc.org
A photocatalytic protocol for the divergent dearomative functionalization of indole derivatives
is reported. Under the irradiation of visible light, either dimerization or reduction occurs …

Photoredox asymmetric nucleophilic dearomatization of indoles with neutral radicals

Y Zhang, P Ji, F Gao, H Huang, F Zeng, W Wang - ACS Catalysis, 2021 - ACS Publications
The dearomatization of indoles represents the most efficient approach for accessing highly
valued indolines. The inherent nucleophilic reactivity of indoles has dictated indole …

Asymmetric dearomatization of indole derivatives with N‐hydroxycarbamates enabled by photoredox catalysis

YZ Cheng, QR Zhao, X Zhang, SL You - Angewandte Chemie, 2019 - Wiley Online Library
Dearomatization of indoles provides efficient synthetic routes for substituted indolines. In
most cases, indoles serve as nucleophiles. Reported here is an asymmetric dearomatization …

Organophotocatalytic dearomatization of indoles, pyrroles and benzo (thio) furans via a Giese-type transformation

Y Zhang, P Ji, F Gao, Y Dong, H Huang… - Communications …, 2021 - nature.com
Accessing fascinating organic and biological significant indolines via dearomatization of
indoles represents one of the most efficient approaches. However, it has been difficult for the …

Direct oxidative dearomatization of indoles: access to structurally diverse 2, 2-disubstituted indolin-3-ones

X Liu, X Yan, Y Tang, CS Jiang, JH Yu… - Chemical …, 2019 - pubs.rsc.org
Described is an efficient oxidative dearomatization of indoles with TEMPO oxoammonium
salt and a broad range of nucleophiles. Under very mild conditions, dearomative …

Visible-light enabled synthesis of cyclopropane-fused indolines via dearomatization of indoles

XL Huang, YZ Cheng, SL You - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
An efficient synthesis of methylene-unsubstituted cyclopropane-fused indolines via
photoredox catalyzed dearomative cyclopropanation of indole derivatives was developed. A …

Decatungstate‐Photocatalyzed Dearomative Hydroacylation of Indoles: Direct Synthesis of 2‐Acylindolines

T Varlet, D Bouchet, E Van Elslande… - … –A European Journal, 2022 - Wiley Online Library
We report herein a convenient and scalable dearomative hydroacylation reaction of indoles.
Employing readily available aldehydes as the acyl source and TBADT as an inexpensive …

Photoredox-catalyzed diastereoselective dearomative prenylation and reverse-prenylation of electron-deficient indole derivatives

X Chang, F Zhang, S Zhu, Z Yang, X Feng… - Nature …, 2023 - nature.com
Prenylated and reverse-prenylated indolines are privileged scaffolds in numerous naturally
occurring indole alkaloids with a broad spectrum of important biological properties …