Introduction Infectious diseases are major causes of morbidity and mortality worldwide,
necessitating the rapid identification and accurate diagnosis of pathogens. While unbiased …

The gold standard for confirming bacterial infections is culture-positive, which has a long
sample-to-result turnaround time and poor sensitivity for unculturable and fastidious …

Serious infections are characterized by rapid progression, poor prognosis, and difficulty in
diagnosis. Recently, a new technique known as nanopore-targeted sequencing (NTS) was …

Background Nanopore sequencing, known for real-time analysis, shows promise for rapid
clinical infection diagnosis but lacks effective assays for bloodstream infections (BSIs) …

Background Nanopore metagenomics has been used for infectious disease diagnosis for
bacterial pathogens. However, this technology currently lacks comprehensive performance …

Abstract Background Bloodstream infections (BSIs) remain a major cause of mortality, in part
due to many patients developing sepsis or septic shock. To survive sepsis, it is paramount …

Cancer patients are at high risk of infections and infection-related mortality; thereby, prompt
diagnosis and precise anti-infectives treatment are critical. This study aimed to evaluate the …

Metagenomic sequencing for infectious disease diagnostics is an important tool that holds
promise for use in the clinical laboratory. Challenges for implementation so far include high …

Rapid and accurate etiologic diagnosis accelerates targeted antimicrobial therapy.
Metagenomic analysis has played a critical role in pathogen identification. In this study, we …

Rapid and accurate pathogen identification is crucial in effectively combating infectious
diseases. However, the current diagnostic tools for bacterial infections predominantly rely on …