Non-invasive assessment and control of ultrasound-mediated membrane permeabilization

J Liu, TN Lewis, MR Prausnitz - Pharmaceutical research, 1998 - Springer
Purpose. Ultrasound has been shown to transiently permeabilize biological membranes,
thereby facilitating delivery of large compounds such as proteins and DNA into cells and …

Duration of ultrasound-mediated enhanced plasma membrane permeability

B Lammertink, R Deckers, G Storm, C Moonen… - International journal of …, 2015 - Elsevier
Ultrasound (US) induced cavitation can be used to enhance the intracellular delivery of
drugs by transiently increasing the cell membrane permeability. The duration of this …

An experimental and theoretical analysis of ultrasound-induced permeabilization of cell membranes

J Sundaram, BR Mellein, S Mitragotri - Biophysical journal, 2003 - cell.com
Application of ultrasound transiently permeabilizes cell membranes and offers a
nonchemical, nonviral, and noninvasive method for cellular drug delivery. Although the …

Over-pressure suppresses ultrasonic-induced drug uptake

SB Stringham, MA Viskovska, ES Richardson… - Ultrasound in medicine …, 2009 - Elsevier
Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer
tissues. The present study further examines the role of acoustic cavitation in US-induced …

Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability

HR Guzman, DX Nguyen, S Khan… - The Journal of the …, 2001 - pubs.aip.org
Ultrasound-mediated drug delivery is a nonchemical, nonviral, and noninvasive method for
targeted transport of drugs and genes into cells. Molecules can be delivered into cells when …

Intracellular drug delivery using low-frequency ultrasound: quantification of molecular uptake and cell viability

K Keyhani, HR Guzmán, A Parsons, TN Lewis… - Pharmaceutical …, 2001 - Springer
Purpose. To determine the dependence on acoustic parameters of molecular uptake and
viability of cells exposed to low-frequency ultrasound. Methods. DU145 prostate cancer cells …

Evaluation of the temporal window for drug delivery following ultrasound-mediated membrane permeability enhancement

A Yudina, M Lepetit-Coiffé, CTW Moonen - Molecular imaging and biology, 2011 - Springer
Purpose Ultrasound-induced cavitation facilitates cellular uptake of drugs via increased
membrane permeability. Here, the purpose was to evaluate the duration of enhanced …

Frequency dependence of sonophoresis

A Tezel, A Sens, J Tuchscherer, S Mitragotri - Pharmaceutical research, 2001 - Springer
Purpose. Application of low-frequency ultrasound has been shown to increase skin
permeability, thereby facilitating delivery of macromolecules (low-frequency sonophoresis) …

Enhancement of non-invasive trans-membrane drug delivery using ultrasound and microbubbles during physiologically relevant flow

FE Shamout, AN Pouliopoulos, P Lee… - Ultrasound in medicine …, 2015 - Elsevier
Sonoporation has been associated with drug delivery across cell membranes and into target
cells, yet several limitations have prohibited further advancement of this technology. Higher …

Can ultrasound enable efficient intracellular uptake of molecules? A retrospective literature review and analysis

Y Liu, J Yan, MR Prausnitz - Ultrasound in medicine & biology, 2012 - Elsevier
Most applications of therapeutic ultrasound (US) for intracellular delivery of drugs, proteins,
DNA/RNA and other compounds would benefit from efficient uptake of these molecules into …