Since the discovery of atrial natriuretic peptide, the unravelling of the natriuretic peptide
system has been a story of scientific success. However, bridging the gap between bench …

Natriuretic peptides play a crucial role in maintaining cardiovascular homeostasis. Among
their properties are vasodilation, natriuresis, diuresis, and inhibition of cardiac remodeling …

The last two centuries have witnessed countless discoveries in the field of medicine that
found their roots in the up growing development of technology as well as in the visionary …

The current standard treatment of chronic heart failure (HF) is based on clinical judgment,
with the goal of achieving the maximally tolerated therapeutic program. The complexity of …

It is now well established that the heart and vascular endothelium are endocrine glands that
synthesize and release natriuretic and vasoactive peptides. Specifically, the cardiac myocyte …

The natriuretic peptide system (NPS) consists of three known peptides which are distinct
gene products and include atrial natriuretic peptide (ANP} and brain natriuretic peptide …

Since the discovery of the cardiac hormone atrial natriuretic peptide by de Bold and
colleagues in 1981, the field of natriuretic peptides has significantly advanced with …

Congestive heart failure has become a major public health problem. A hallmark of this
syndrome is neurohumoral activation, with elevation of natriuretic peptides, in particular …

The longstanding conventional view of the natriuretic peptide system is one in which the
natriuretic peptides form an important cardiorenal endocrine axis. Specifically, the heart …

The natriuretic peptides are a family of widely distributed, but evolutionarily conserved,
polypeptide mediators that exert a range of actions throughout the body. In cardiovascular …