A new approach to improve the specificity of flow-mediated dilation for indicating endothelial function in cardiovascular research

G Atkinson, AM Batterham, DHJ Thijssen… - Journal of …, 2013 - journals.lww.com
Flow-mediated dilation (FMD) is a noninvasive indicator of endothelial function and is
routinely expressed as the percentage change in arterial diameter (FMD%) from a resting …

Allometric scaling of diameter change in the original flow-mediated dilation protocol

G Atkinson, AM Batterham - Atherosclerosis, 2013 - Elsevier
The negative correlation between percent flow-mediated dilation (FMD%) and baseline
diameter (Dbase) has only recently been recognised as a fundamental ratio-scaling …

The percentage flow-mediated dilation index: A large-sample investigation of its appropriateness, potential for bias and causal nexus in vascular medicine

G Atkinson, AM Batterham - Vascular medicine, 2013 - journals.sagepub.com
The percentage flow-mediated dilation index (FMD%) scales the increase in arterial
diameter (Ddiff) as a constant proportion of baseline artery diameter (Dbase). We have …

Flow-mediated dilation reference values for evaluation of endothelial function and cardiovascular health

C Heiss, A Rodriguez-Mateos, M Bapir… - Cardiovascular …, 2023 - academic.oup.com
Aims Endothelial function is essential for cardiovascular health, and flow-mediated dilation
(FMD) is an established technique to measure it. This paper aims to assess FMD values in …

Evaluation of endothelial function by flow mediated dilation: methodological issues and clinical importance

L Ghiadoni, M Salvetti, ML Muiesan… - High blood pressure & …, 2015 - Springer
Endothelium plays a primary role in the control of vascular function and structure by
protective properties of nitric oxide, which have stimulated the development of methods to …

Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study

L Ghiadoni, F Faita, M Salvetti, C Cordiano… - Journal of …, 2012 - journals.lww.com
Objective: Impaired flow-mediated dilation (FMD) is associated with cardiovascular risk
factors and provides prognostic information. Despite the noninvasive nature of this …

Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans

DHJ Thijssen, RM Bruno, ACCM van Mil… - European heart …, 2019 - academic.oup.com
Endothelial dysfunction is involved in the development of atherosclerosis, which precedes
asymptomatic structural vascular alterations as well as clinical manifestations of …

Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation

AE Donald, JP Halcox, M Charakida, C Storry… - Journal of the American …, 2008 - jacc.org
Objectives: Our aim was to determine reproducibility of the flow-mediated dilation (FMD)
response profile, and discriminatory ability of the components. Background: Brachial FMD is …

Assessment of flow-mediated dilation in humans: a methodological and physiological guideline

DHJ Thijssen, MA Black, KE Pyke… - American Journal …, 2011 - journals.physiology.org
Endothelial dysfunction is now considered an important early event in the development of
atherosclerosis, which precedes gross morphological signs and clinical symptoms. The …

Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?

DR Witte, J Westerink, EJ de Koning… - Journal of the American …, 2005 - jacc.org
Objectives: The aim of this research was to study whether the relation between endothelial
function measured by flow-mediated dilation (FMD) of the brachial artery and cardiovascular …