Normal hematopoiesis is sustained through a carefully orchestrated balance between
hematopoietic stem cell (HSC) self-renewal and differentiation. The functional importance of …

RNA-binding proteins (RBPs) regulate fundamental processes, such as differentiation and
self-renewal, by enabling the dynamic control of protein abundance or isoforms or through …

Posttranscriptional regulation of mRNA is a powerful and tightly controlled process in which
cells command the integrity, diversity, and abundance of their protein products. RNA-binding …

Acute myeloid leukemia (AML) is a common and aggressive hematological malignancy.
Acquisition of heterogeneous genetic aberrations and epigenetic dysregulation lead to the …

RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA
processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant …

The discovery of micro RNA s has renewed interest in posttranscriptional modes of
regulation, fueling an emerging view of a rich RNA world within our cells that deserves …

Throughout their life span, multicellular organisms rely on stem cell systems. During
development pluripotent embryonic stem cells give rise to all cell types that make up the …

Hematological malignancies comprise a plethora of different neoplasms, such as leukemia,
lymphoma, and myeloma, plus a myriad of dysplasia, such as myelodysplastic syndromes or …

Acute leukemias are genetic diseases caused by translocations or mutations, which
dysregulate hematopoiesis towards malignant transformation. However, the molecular mode …

Ribosomal RNAs (rRNAs) are the most abundant cellular RNAs, and their synthesis from
rDNA repeats by RNA polymerase I accounts for the bulk of all transcription. Despite …