Genome-wide linkage analysis was performed for systolic and diastolic blood pressures in
the Hypertension Genetic Epidemiology Network. We investigated the role of gene–age …

Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …

Hypertension is an important determinant of cardiovascular morbidity and mortality and has
a substantial heritability, which is likely of polygenic origin. The aim of this study was to …

The role of heredity in influencing blood pressure and risk of hypertension is well
recognized. However, progress in identifying specific genetic variation that contributes to …

Recently, large-scale meta-analyses of genome-wide association (GWA) studies have
identified a number of loci significantly associated with systolic and/or diastolic blood …

Hypertension is among the first traits studied using genome-wide association study (GWAS).
At first, GWAS by the Well-come Trust Case Control Consortium in 2007 did not identify any …

Background A recent genome wide association study in 1017 African Americans identified
several single nucleotide polymorphisms that reached genome-wide significance for systolic …

This brief commentary is based on the debate that took part in May 2010 in New York. We
describe the initial difficulties experienced in early genome-wide association studies of …

The genetic mechanisms that control variation in blood pressure level are largely unknown.
One of the first steps in understanding those mechanisms is the localization of the genes that …

Unfortunately, the contribution of the majority of association studies so far to our
understanding of the genetic determinants of hypertension remains largely negligible. For …