Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Natural killer (NK) cells are lymphocytes of the innate immune system. They not only exert
cell-mediated cytotoxicity against tumor cells or infected cells, but also play regulatory role …

The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution
of genetic and environmental factors is generally recognized. Despite autoimmune …

Natural killer (NK) cells are part of the innate-immune system and respond rapidly to a
variety of insults via cytokine secretion and cytolytic activity. Their main function is first line of …

As major components of innate immunity, NK cells not only exert cell-mediated cytotoxicity
against tumor cells or infected cells, but also act to regulate the function of other immune …

Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid
killing of infected and transformed cells without preactivation provides a first line of defense …

Increasing evidences have pointed out the relevance of natural killer (NK) cells in organ-
specific and systemic autoimmune diseases. NK cells bear a plethora of activating and …

Natural killer (NK) cells were once regarded as relatively simple cells of the innate immune
system. However, they are now revealing themselves as multifunctional regulatory cells that …

Autoimmune diseases are chronic conditions resulting from a loss of immunological
tolerance to self‐antigens. Recent observations have supported an ever‐broader role for …

Autoimmune diseases recognize a multifactorial pathogenesis, although the exact
mechanism responsible for their onset remains to be fully elucidated. Over the past few …