The role of organo-fluorine compounds in modern health, food and energy related industries
is widely-appreciated. The unique properties that fluorine imparts to organic molecules …

Advances in the development of newly developed fluorinated drugs, approved or in clinical
trials, as organized by biological targets/disease states, are reviewed. In a few cases …

It has become evident that fluorinated compounds have a remarkable record in medicinal
chemistry and will play a continuing role in providing lead compounds for therapeutic …

Organic fluorine compounds have had a profound impact on the development of bioactives
for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals …

Drug candidates with one or more fluorines have become commonplace. The special nature
of fluorine imparts a variety of properties to certain medicines, including enhanced binding …

Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Thirteen new fluorine-containing drugs, which have been granted approval by the US Food
and Drug Administration (FDA) in 2020, are profiled in this review. Therapeutic areas of …

Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in
the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro …

Introduction of novel and diverse functional groups in drug discovery is always seen with
hesitancy until good activity and low toxicity characteristics are proven. The introduction of …

1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …