Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear

GL Dalton, YT Wang, SB Floresco… - …, 2008 - nature.com
Synaptic plasticity in the form of long-term potentiation (LTP) plays a critical role in the
formation of a Pavlovian fear association. However, the role that synaptic plasticity plays in …

Altered AMPA receptor expression plays an important role in inducing bidirectional synaptic plasticity during contextual fear memory reconsolidation

S Bhattacharya, W Kimble, M Buabeid… - Neurobiology of learning …, 2017 - Elsevier
Retrieval of a memory appears to render it unstable until the memory is once again re-
stabilized or reconsolidated. Although the occurrence and consequences of reconsolidation …

Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory

HC Lin, SC Mao, CL Su, PW Gean - International Journal of …, 2010 - academic.oup.com
Understanding the neurophysiology of fear extinction has important implications for the
treatment of post-traumatic stress disorders. Here we report that fear conditioning resulted in …

Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memory

T Sigurdsson, V Doyère, CK Cain, JE LeDoux - Neuropharmacology, 2007 - Elsevier
Much of the research on long-term potentiation (LTP) is motivated by the question of whether
changes in synaptic strength similar to LTP underlie learning and memory. Here we discuss …

Endogenous GluR1‐containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: an …

H Nedelescu, CM Kelso… - Journal of …, 2010 - Wiley Online Library
Abstract Although glutamate receptor 1 (GluR1)‐containing α‐amino‐3‐hydroxyl‐5‐methyl‐
4‐isoxazole‐propionate receptors (GluR1‐AMPARs) are implicated in synaptic plasticity, it …

Impaired associative fear learning in mice with complete loss or haploinsufficiency of AMPA GluR1 receptors

M Feyder, L Wiedholz, R Sprengel… - Frontiers in behavioral …, 2007 - frontiersin.org
There is compelling evidence that L-alpha-amino-3-hydroxy-5-methylisoxazole-4-
propionate (AMPA) glutamate receptors containing the GluR1 subunit contribute to the …

AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired

MT Rogan, UV Stäubli, JE LeDoux - Journal of Neuroscience, 1997 - Soc Neuroscience
Rats treated with the AMPA receptor-facilitating drug 1-(quinoxolin-6-ylcarbonyl) piperidine
(BDP-12) during training acquired fear conditioning to a tone faster than vehicle-treated …

NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral …

EP Bauer, GE Schafe, JE LeDoux - Journal of Neuroscience, 2002 - Soc Neuroscience
Long-term potentiation (LTP) at sensory input synapses to the lateral amygdala (LA) is a
candidate mechanism for memory storage during fear conditioning. We evaluated the effect …

[HTML][HTML] Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex

A Burgos-Robles, I Vidal-Gonzalez, E Santini, GJ Quirk - Neuron, 2007 - cell.com
Extinction of conditioned fear is an active learning process requiring N-methyl-D-aspartate
receptors (NMDARs), but the timing, location, and neural mechanisms of NMDAR-mediated …

Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition

H Shaban, Y Humeau, C Herry, G Cassasus… - Nature …, 2006 - nature.com
Pavlovian fear conditioning, a simple form of associative learning, is thought to involve the
induction of associative, NMDA receptor–dependent long-term potentiation (LTP) in the …