An L5 spinal nerve ligation (SNL) in the rat leads to behavioral signs of mechanical
hyperalgesia. Our recent finding that an L5 dorsal root rhizotomy did not alter the …

Mechanical allodynia-and hyperalgesia-like behavior which develops in rats after L5 spinal
nerve lesion has been suggested to be due to ectopic activity in the lesioned afferent …

An injury to a peripheral nerve in animals often leads to signs of neuropathic pain including
hyperalgesia to heat, cold and mechanical stimuli. The role of injured and intact nerve fibers …

The L5 spinal nerve ligation (SNL) is a widely used animal neuropathic pain model. There
are conflicting reports regarding the extent of injury to the L4 dorsal root ganglion (DRG) …

Ligation and transection of the L5 spinal nerve in the rat lead to behavioral signs of pain and
hyperalgesia. Discharge of injured nociceptors has been presumed to play a role in …

The relationship between pain severity and the extent of injury to a peripheral nerve remains
elusive. In this study, we compared the pain behavior resulting from partial (1/3–1/2 …

L5 and L6 spinal nerve ligation (SNL) in rats leads to behavioral signs of neuropathic pain
including mechanical allodynia. The purposes of this study were to investigate the role of the …

We investigated behavioral symptoms of neuropathic pain, and associated changes in
dorsal horn neurons, in a rat model involving loose ligation of lumbar dorsal roots. The L4 …

Tight ligation of the fifth and sixth lumbar segmental nerves in the rat provides a model of
neuropathic pain. We used this model to assess the changes in primary afferent input to the …

Spinal nerve L5/L6 ligation (SNL) in rats has become the standard for mechanistic studies of
peripheral neuropathy and screening for novel analgesics. Conventional SNL in our hybrid …