Objectives Epigenetic modifications are closely linked with aging, but their relationship with
cognition remains equivocal. Given known sex differences in epigenetic aging, we explored …

Background and Objectives Exposure to socioeconomic disadvantage is associated with
early-onset cognitive aging. Biological aging, the progressive loss of system integrity that …

Background Little is known about the role of DNA methylation (DNAm) epigenetic age
acceleration in cognitive decline. Using a twin study design, we examined whether DNAm …

The relationship between cognitive performance, macro and microstructural brain anatomy
and accelerated aging as measured by a highly accurate epigenetic biomarker of aging …

Background and Objectives DNA methylation algorithms are increasingly used to estimate
biological aging; however, how these proposed measures of whole-organism biological …

Methylation levels measured at defined sites across the genome have recently been shown
to be correlated with an individual's chronological age. Age acceleration, or the difference …

Objective This study tests associations of DNA methylation-based (DNAm) measures of
epigenetic age acceleration (EAA) with cross-sectional and longitudinal depressive …

The identification of biomarkers that discriminate individual ageing trajectories is a principal
target of ageing research. Some of the most promising predictors of biological ageing have …

Background and Objectives In multiple sclerosis (MS), accelerated aging of the immune
system (immunosenescence) may be associated with disease onset or drive progression …

DNA methylation-based (DNAm) measures of biological aging associate with increased risk
of morbidity and mortality, but their links with cognitive decline are less established. This …