This article describes the prefabrication of a vascularized bone graft composed of
autologous particulate cancellous bone and marrow (PCBM), a vessel bundle, and a …

The repair of bone defects remains a major clinical challenge because none available
reconstruction methods and biomaterials have been proved completely satisfactory. As a …

The repair of bone defects poses a great challenge for reconstructive surgeons. Although
the development of tißsue engineering has exhibited promise in replacing damaged bone …

It is a common treatment strategy in the clinic to transplant a vascularized bone flap for a
large bone defect. But it is difficult for peripheral blood vessels to grow into the central region …

Background: The regeneration of large, poorly vascularized bone defects remains a
significant challenge. Although vascularized bone grafts promote osteogenesis, the required …

Vascularization of engineered bone tissue is critical for ensuring its survival after
implantation. In vitro pre-vascularization of bone grafts with endothelial cells is a promising …

The aim of this project was to construct vascularized tissue‐engineered living bone with an
autologous vascular network by means of a rabbit bioreactor in vivo. The key components of …

Bone is one of the most vascular network-rich tissues in the body and the vascular system is
essential for the development, homeostasis, and regeneration of bone. When segmental …

Vascularization of large bone grafts is one of the main challenges of bone tissue
engineering (BTE), and has held back the clinical translation of engineered bone constructs …

Introduction: Vascularization remains an obstacle to engineering of larger volume bone
tissues. Our aim was to induce axial vascularization in a processed bovine cancellous bone …