Aims: Inorganic nitrate and nitrite from endogenous and dietary sources have emerged as
alternative substrates for nitric oxide (NO) formation in addition to the classic L-arginine NO …

Since the first demonstration of Nox enzyme expression in the kidney in the early 1990s and
the subsequent identification of Nox4, or RENOX, a decade later, it has become apparent …

The characterization and cloning of constitutive and inducible nitric oxide (NO)-synthesizing
enzymes and the development of specific inhibitors of the L-arginine NO pathway have …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Renal function is highly dependent on endothelium-derived nitric oxide (NO). Several renal
disorders have been linked to impaired NO bioavailability. The enzyme that is responsible …

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …

Inorganic nitrite, a metabolite of endogenously produced nitric oxide (NO) from NO
synthases (NOS), provides the largest endocrine source of directly bioavailable NO. The …

The nitrate-nitrite-NO pathway is emerging as a likely regulator of physiological functions in
the gastrointestinal tract and in the cardiovascular system. In particular, it might serve as a …

Nitric oxide (NO) is generated endogenously by NO synthases to regulate a number of
physiological processes including cardiovascular and metabolic functions. A decrease in the …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …