Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS …

Endothelial production of nitric oxide (NO) is critical for vascular homeostasis. Nitrite and
nitrate are formed endogenously by the stepwise oxidation of NO and have, for years, been …

Although initially adaptive, the changes that accompany hypertension, namely, cell growth,
endothelial dysfunction, and extracellular matrix deposition, eventually can become …

Noxes, which are differentially regulated in hypertension, are major sources of
cardiovascular and renal oxidative stress. This has evoked considerable interest because of …

The endothelium plays an important role in the maintenance of vascular homeostasis.
Central to this role is the endothelial production of nitric oxide (NO), synthesized by the …

During the last decade, a multitude of experimental arguments have led to the concept that
EDRF is nitric oxide (NO), a messenger not only involved in the control of vasomotor tone …

The inorganic anions nitrate (NO3−) and nitrite (NO2−) were previously thought to be inert
end products of endogenous nitric oxide (NO) metabolism. However, recent studies show …

Endothelial dysfunction is characterized by a vasoconstrictive and prothrombotic state in the
vasculature; it plays a role in all stages of cardiac disease and is a significant independent …

The discovery of nitric oxide and its role in almost every facet of human biology opened a
new avenue for treatment through manipulation of its canonical signaling and by attempts to …

Nitric oxide, oxidative stress, and apoptosis. Life demands intra-and intercellular
communication in and between cells to respond and adapt to changes in the environment …