Clinical genetic counseling and translation considerations for polygenic scores in personalized risk assessments: a practice resource from the national society of …

H Wand, SS Kalia, BM Helm, SA Suckiel… - Journal of genetic …, 2023 - Wiley Online Library
Polygenic scores (PGS) are primed for use in personalized risk assessments for common,
complex conditions and population health screening. Although there is growing evidence …

How can we address the uncertainties regarding the potential clinical utility of polygenic score-based tests?

S Moorthie, A Hall, C Babb de Villiers… - Personalized …, 2022 - Taylor & Francis
As common low penetrance variants associated with diseases are uncovered, attempts
continue to be made to harness this knowledge for improving healthcare. Polygenic scores …

Recent advances in polygenic scores: translation, equitability, methods and FAIR tools

R Xiang, M Kelemen, Y Xu, LW Harris, H Parkinson… - Genome Medicine, 2024 - Springer
Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic
predisposition to disease, and many potentially clinically useful applications have been …

Human genetics society of Australasia position statement: use of polygenic scores in clinical practice and population health

MA Young, T Yanes, AE Cust, K Dunlop… - Twin Research and …, 2023 - cambridge.org
Considerable progress continues to be made with regards to the value and use of disease
associated polygenic scores (PGS). PGS aim to capture a person's genetic liability to a …

Polygenic risk scores in the clinic: translating risk into action

ACF Lewis, RC Green, JL Vassy - Human Genetics and Genomics …, 2021 - cell.com
Polygenic risk scores (PRSs) are heralded as useful tools for risk stratification and
personalized preventive care, but they are clinically useful only if they can be translated into …

Has the genome granted our wish yet?

DJ Hunter, JM Drazen - New England Journal of Medicine, 2019 - Mass Medical Soc
Has the Genome Granted Our Wish Yet? Interpretation of polygenic risk scores will someday
become an accepted part of clinical practice—but not just yet. It is, however, time to evaluate …

Education and electronic medical records and genomics network, challenges, and lessons learned from a large-scale clinical trial using polygenic risk scores

JJ Connolly, ES Berner, M Smith, S Levy, S Terek… - Genetics in …, 2023 - Elsevier
Polygenic risk scores (PRS) have potential to improve health care by identifying individuals
that have elevated risk for common complex conditions. Use of PRS in clinical practice …

Improving reporting standards for polygenic scores in risk prediction studies

H Wand, SA Lambert, C Tamburro, MA Iacocca… - Nature, 2021 - nature.com
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …

[HTML][HTML] Addressing the challenges of polygenic scores in human genetic research

J Novembre, C Stein, S Asgari… - The American Journal of …, 2022 - cell.com
The genotyping of millions of human samples has made it possible to evaluate variants
across the human genome for their possible association with risks for numerous diseases …

[HTML][HTML] The clinical application of polygenic risk scores: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG)

A Abu-El-Haija, HV Reddi, H Wand, NC Rose… - Genetics in …, 2023 - Elsevier
Polygenic inheritance is a non-Mendelian form of inheritance in which the risk of a trait,
disorder, or disease results from the combined contribution of variants from multiple genes …