S Moorthie, A Hall, C Babb de Villiers… - Personalized …, 2022 - Taylor & Francis
As common low penetrance variants associated with diseases are uncovered, attempts continue to be made to harness this knowledge for improving healthcare. Polygenic scores …
Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic predisposition to disease, and many potentially clinically useful applications have been …
Considerable progress continues to be made with regards to the value and use of disease associated polygenic scores (PGS). PGS aim to capture a person's genetic liability to a …
ACF Lewis, RC Green, JL Vassy - Human Genetics and Genomics …, 2021 - cell.com
Polygenic risk scores (PRSs) are heralded as useful tools for risk stratification and personalized preventive care, but they are clinically useful only if they can be translated into …
DJ Hunter, JM Drazen - New England Journal of Medicine, 2019 - Mass Medical Soc
Has the Genome Granted Our Wish Yet? Interpretation of polygenic risk scores will someday become an accepted part of clinical practice—but not just yet. It is, however, time to evaluate …
JJ Connolly, ES Berner, M Smith, S Levy, S Terek… - Genetics in …, 2023 - Elsevier
Polygenic risk scores (PRS) have potential to improve health care by identifying individuals that have elevated risk for common complex conditions. Use of PRS in clinical practice …
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association studies, can bridge the gap between initial discovery efforts and clinical applications for the …
The genotyping of millions of human samples has made it possible to evaluate variants across the human genome for their possible association with risks for numerous diseases …
A Abu-El-Haija, HV Reddi, H Wand, NC Rose… - Genetics in …, 2023 - Elsevier
Polygenic inheritance is a non-Mendelian form of inheritance in which the risk of a trait, disorder, or disease results from the combined contribution of variants from multiple genes …