Characterisation of the pro-inflammatory cytokine signature in severe COVID-19

HC Hawerkamp, AH Dyer, ND Patil… - Frontiers in …, 2023 - frontiersin.org
Clinical outcomes from infection with SARS-CoV-2, the cause of the COVID-19 pandemic,
are remarkably variable ranging from asymptomatic infection to severe pneumonia and …

Longitudinal cytokine profile in patients with mild to critical COVID-19

L Ling, Z Chen, G Lui, CK Wong, WT Wong… - Frontiers in …, 2021 - frontiersin.org
The cytokine release syndrome has been proposed as the driver of inflammation in
coronavirus disease 2019 (COVID-19). However, studies on longitudinal cytokine profiles in …

The role of immunological and clinical biomarkers to predict clinical COVID-19 severity and response to therapy—a prospective longitudinal study

A Copaescu, F James, E Mouhtouris, S Vogrin… - Frontiers in …, 2021 - frontiersin.org
Background The association of pro-inflammatory markers such as interleukin-6 (IL-6) and
other biomarkers with severe coronavirus disease 2019 (COVID-19) is of increasing interest …

Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19

NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …

A deep look into COVID-19 severity through dynamic changes in blood cytokine levels

DA Kleymenov, EN Bykonia, LI Popova… - Frontiers in …, 2021 - frontiersin.org
An excessive inflammatory response to SARS-CoV-2 is thought to be a major cause of
disease severity and mortality in patients with COVID-19. Longitudinal analysis of cytokine …

[HTML][HTML] The immune response and immunopathology of COVID-19

E Mortaz, P Tabarsi, M Varahram, G Folkerts… - Frontiers in …, 2020 - frontiersin.org
Coronaviruses were first discovered in the 1960s and are named due to their crown-like
shape. Sometimes, but not often, a coronavirus can infect both animals and humans. An …

Immunological and inflammatory profiles in mild and severe cases of COVID-19

JW Song, C Zhang, X Fan, FP Meng, Z Xu, P Xia… - Nature …, 2020 - nature.com
Abstract COVID-19 is associated with 5.1% mortality. Although the virological,
epidemiological, clinical, and management outcome features of COVID-19 patients have …

Distinct cytokine profiles associated with COVID-19 severity and mortality

K Dorgham, P Quentric, M Gökkaya, S Marot… - Journal of Allergy and …, 2021 - Elsevier
Background Markedly elevated levels of proinflammatory cytokines and defective type-I
interferon responses were reported in patients with coronavirus disease 2019 (COVID-19) …

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

PA Mudd, JC Crawford, JS Turner, A Souquette… - Science …, 2020 - science.org
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …

[HTML][HTML] Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis

JG Wilson, LJ Simpson, AM Ferreira, A Rustagi… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Elevated levels of inflammatory cytokines have been associated with poor
outcomes among COVID-19 patients. It is unknown, however, how these levels compare …