Genome-wide association studies (GWAS) have heralded a new era in susceptibility locus
discovery in complex diseases. For type 1 diabetes,> 40 susceptibility loci have been …

Aims/hypothesis Type 2 diabetes is a growing global public health challenge. Investigating
quantitative traits, including fasting glucose, fasting insulin and HbA1c, that serve as early …

The field of complex disease genetics has witnessed rapid progress over the past few
months. The advent of genome-wide association scans (GWAS) has mediated a change in …

Advances in molecular methods and the ability to share large population-based datasets are
uncovering heterogeneity within diabetes types, and some commonalities between types …

Diabetes impacts approximately 200 million people worldwide, of whom approximately 10%
are affected by type 1 diabetes (T1D). The application of genome-wide association studies …

Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in
populations of European and Asian ancestry. We tested whether the direction of association …

Eur J Clin Invest 2011; 41 (6): 679–692 Abstract Background Recent genome‐wide
association studies enlarged our knowledge about the genetic background of type 2 …

Abstract The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide
association (GWA) scan on seven diseases, including the multifactorial autoimmune disease …

Type 1 Diabetes (T1D) is a chronic multifactorial disease with a strong genetic component,
which, through interactions with specific environmental factors, triggers disease onset. T1D …

Genome-wide association studies (GWAS) have uncovered> 65 common variants
associated with type 2 diabetes (T2D); however, their relevance for drug development is not …