Long-term response to genomic selection: effects of estimation method and reference population structure for different genetic architectures
JWM Bastiaansen, A Coster, MPL Calus… - Genetics Selection …, 2012 - Springer
Background Genomic selection has become an important tool in the genetic improvement of
animals and plants. The objective of this study was to investigate the impacts of breeding …
animals and plants. The objective of this study was to investigate the impacts of breeding …
The importance of information on relatives for the prediction of genomic breeding values and the implications for the makeup of reference data sets in livestock …
Background The theory of genomic selection is based on the prediction of the effects of
genetic markers in linkage disequilibrium with quantitative trait loci. However, genomic …
genetic markers in linkage disequilibrium with quantitative trait loci. However, genomic …
Persistence of accuracy of genome-wide breeding values over generations when including a polygenic effect
TR Solberg, AK Sonesson, JA Woolliams… - Genetics Selection …, 2009 - Springer
Background When estimating marker effects in genomic selection, estimates of marker
effects may simply act as a proxy for pedigree, ie their effect may partially be attributed to …
effects may simply act as a proxy for pedigree, ie their effect may partially be attributed to …
Genomic selection requires genomic control of inbreeding
AK Sonesson, JA Woolliams… - Genetics Selection …, 2012 - Springer
Background In the past, pedigree relationships were used to control and monitor inbreeding
because genomic relationships among selection candidates were not available until …
because genomic relationships among selection candidates were not available until …
Different models of genetic variation and their effect on genomic evaluation
Background The theory of genomic selection is based on the prediction of the effects of
quantitative trait loci (QTL) in linkage disequilibrium (LD) with markers. However, there is …
quantitative trait loci (QTL) in linkage disequilibrium (LD) with markers. However, there is …
The long-term effects of genomic selection: 1. Response to selection, additive genetic variance, and genetic architecture
Background Genomic selection has revolutionized genetic improvement in animals and
plants, but little is known about its long-term effects. Here, we investigated the long-term …
plants, but little is known about its long-term effects. Here, we investigated the long-term …
Reducing dimensionality for prediction of genome-wide breeding values
TR Solberg, AK Sonesson, JA Woolliams… - Genetics Selection …, 2009 - Springer
Partial least square regression (PLSR) and principal component regression (PCR) are
methods designed for situations where the number of predictors is larger than the number of …
methods designed for situations where the number of predictors is larger than the number of …
Allele frequency changes due to hitch-hiking in genomic selection programs
H Liu, AC Sørensen, THE Meuwissen… - Genetics Selection …, 2014 - Springer
Background Genomic selection makes it possible to reduce pedigree-based inbreeding over
best linear unbiased prediction (BLUP) by increasing emphasis on own rather than family …
best linear unbiased prediction (BLUP) by increasing emphasis on own rather than family …
Response to genomic selection: The Bulmer effect and the potential of genomic selection when the number of phenotypic records is limiting
EM Van Grevenhof, JAM Van Arendonk… - Genetics Selection …, 2012 - Springer
Background Over the last ten years, genomic selection has developed enormously.
Simulations and results on real data suggest that breeding values can be predicted with …
Simulations and results on real data suggest that breeding values can be predicted with …
Pre-selection of markers for genomic selection
Background Accurate prediction of genomic breeding values (GEBVs) requires numerous
markers. However, predictive accuracy can be enhanced by excluding markers with no …
markers. However, predictive accuracy can be enhanced by excluding markers with no …