Outcomes of tocilizumab therapy in severe or critical COVID‐19 patients: A retrospective cohort, single‐centre study

H Abdelnaby, W Aboelhassan… - Tropical Medicine & …, 2021 - Wiley Online Library
Objectives To assess the effectiveness and safety of tocilizumab, a humanised anti‐
interleukin‐6 receptor antibody, in the treatment of critical or severe coronavirus disease …

A retrospective evaluation of COVID-19 patients treated with Tocilizumab: who should be treated?

SÇ Ekinci, SA Işık - The Journal of Infection in Developing Countries, 2021 - jidc.org
Introduction: Tocilizumab, can be used in the treatment of COVID-19 in patients developing
cytokine storms. This study retrospectively evaluated patients treated with Tocilizumab …

[HTML][HTML] Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and antibody responses in patients with COVID-19: A prospective cohort study

M Masiá, M Fernández-González, S Padilla… - …, 2020 - thelancet.com
Background The virological and immunological effects of the immunomodulatory drugs used
for COVID-19 remain unknown. We evaluated the impact of interleukin (IL)-6 blockade with …

Tocilizumab treatment in COVID‐19: a single center experience

P Luo, Y Liu, L Qiu, X Liu, D Liu… - Journal of medical …, 2020 - Wiley Online Library
Tocilizumab (TCZ), a monoclonal antibody against interleukin‐6 (IL‐6), emerged as an
alternative treatment for COVID‐19 patients with a risk of cytokine storms recently. In the …

Tocilizumab for the treatment of adult patients with severe COVID‐19 pneumonia: a single‐center cohort study

M Fernández‐Ruiz, F López‐Medrano… - Journal of medical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) can lead to a massive cytokine release. The
use of the anti‐interleukin‐6 receptor monoclonal antibody tocilizumab (TCZ) has been …

Even one dose of tocilizumab could hinder bad prognosis of cytokines storm in COVID-19 patients

MAS Elgohary, A Ali, SJ Alarfaj, H Shahin, AI Zaki… - Cytokine, 2024 - Elsevier
Severe COVID-19 pneumonia is a principal cause of death due to cascade of hyper
inflammatory condition that leading to lung damage. Therefore, an effective therapy to …

[HTML][HTML] Analysis of the factors predicting clinical response to tocilizumab therapy in patients with severe COVID-19

R San-Juan, M Fernández-Ruiz… - International Journal of …, 2022 - Elsevier
Background Controversy remains about the efficacy of tocilizumab (TCZ) for the treatment of
severe COVID-19. We aimed to analyze the profile of TCZ-respondent patients. Methods We …

[PDF][PDF] Influence of tocilizumab on the outcome of patients with COVID-19. retrospective observational study

EI Davidescu, I Odajiu, MD Ilie, T Bunea, G Sandu… - Farmacia, 2020 - researchgate.net
Cytokine storm seems to be one of the main culprits for developing a severe form of COVID-
19, IL-6 being one of its basic components. Therefore, currently, tocilizumab is widely …

Efficacy of Tocilizumab in COVID‐19: single‐center experience

S Kaya, S Kavak - BioMed Research International, 2021 - Wiley Online Library
Background. Cytokine release syndrome can be observed during the course of COVID‐19.
Tocilizumab is used for treating this highly fatal syndrome. We think that the starting time of …

[HTML][HTML] Intravenous Tocilizumab versus Standard of Care in the Treatment of Severe and Critical COVID-19-related Pneumonia: A Single-center, Double-blind …

EJB Amante, AS David-Wang, ML Tee… - Acta Medica …, 2024 - ncbi.nlm.nih.gov
Background Severe and critical COVID-19 disease is characterized by hyperinflammation
involving pro-inflammatory cytokines, particularly IL-6. Tocilizumab is a monoclonal antibody …