Low‐dose tocilizumab is associated with improved outcome and a low risk of secondary infection in severe COVID‐19 pneumonia

I Celik, E Eryilmaz‐Eren, A Kilinc‐Toker… - … Journal of Clinical …, 2021 - Wiley Online Library
Background Respiratory failure and death are the leading causes of severe Coronavirus
disease 2019 (COVID‐19). Hyper‐inflammation and cytokine storm cause lung damage …

TOCIVID-19-A multicenter study on the efficacy and tolerability of tocilizumab in the treatment of patients with COVID-19 pneumonia. Study protocol

MC Piccirillo, P Ascierto, L Atripaldi, M Cascella… - Contemporary clinical …, 2020 - Elsevier
Background Pneumonia is the most frequent complication of COVID-19, due to an aberrant
host immune response that is associated with an acute respiratory distress syndrome, and …

[HTML][HTML] Evaluating the Effects of Nebulized Tocilizumab versus Intravenous Tocilizumab in the Management of Severe Coronavirus Disease 2019 Cases: A …

F Dastan, S Barati, A Fakharian… - Biomedical and …, 2023 - journals.lww.com
Background: Tocilizumab has shown promising effects in the management of coronavirus
disease 2019 (COVID-19) patients. Nebulized tocilizumab might reduce this inflammation …

Tocilizumab use in COVID‐19‐associated pneumonia

AK Okoh, E Bishburg, S Grinberg… - Journal of medical …, 2021 - Wiley Online Library
Background We sought to evaluate the effect of tocilizumab (TCB), a recombinant
humanized monoclonal antibody against soluble interleukin‐6 receptors, in patients …

[HTML][HTML] “Tocilizumab-an option for patients with COVID-19 associated cytokine release syndrome: A single center experience”, a retrospective study-original article

AZK Chachar, KA Khan, J Iqbal, AH Shahid… - Annals of Medicine and …, 2021 - Elsevier
Background The first case of Infection with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) was diagnosed in Wuhan, China in 2019. In the first half of 2020, this disease …

Tocilizumab for COVID-19: a real 'miracle drug'?

S Nasim, SH Hashmi, D Azim, S Kumar… - Infectious …, 2020 - Taylor & Francis
To the Editor, A recent report in this journal described the severe nature and potentially fatal
outcome of COVID-19 [1]. The coronavirus disease, identified as COVID-19, has rapidly …

Tocilizumab for the Treatment of COVID-19

R Flisiak, M Flisiak-Jackiewicz, P Rzymski… - Expert Review of Anti …, 2023 - Taylor & Francis
Introduction Since the beginning of the COVID-19 pandemic, the repurposing of medicines
has been pursued to find interventions effective in preventing fatal outcome of the disease …

[HTML][HTML] Administration timing and efficacy of tocilizumab in patients with COVID-19 and elevated IL-6

P Li, Z Lu, Q Li, Z Wang, Y Guo, C Cai… - Frontiers in molecular …, 2021 - frontiersin.org
Background Tocilizumab (TCZ), an interleukin-6 receptor antibody, has previously been
used for treating patients with the coronavirus disease 2019 (COVID-19), but there is a lack …

Comparing efficacy and safety of tocilizumab and methylprednisolone in the treatment of patients with severe COVID-19

L Abbasian, N Toroghi, H Rahmani, H Khalili… - International …, 2022 - Elsevier
Objectives This study was designed to compare the efficacy and safety of
methylprednisolone and tocilizumab in the treatment of patients with severe COVID-19 …

[HTML][HTML] Impact of tocilizumab administration on mortality in severe COVID-19

A Tsai, O Diawara, RG Nahass, L Brunetti - Scientific reports, 2020 - nature.com
The novel coronavirus disease 2019 (COVID-19) worldwide pandemic has placed a
significant burden on hospitals and healthcare providers. The immune response to this …