Safety and efficacy of anti-il6-receptor tocilizumab use in severe and critical patients affected by coronavirus disease 2019: A comparative analysis

R Rossotti, G Travi, N Ughi, M Corradin, C Baiguera… - Journal of Infection, 2020 - Elsevier
Background As the novel SARS-CoV-2 pandemic occurred, no specific treatment was yet
available. Inflammatory response secondary to viral infection might be the driver of severe …

[HTML][HTML] Clinical predictors of response to tocilizumab: A retrospective multicenter study

S Ercan, B Ergan, SS Özuygur, P Korkmaz… - Turkish thoracic …, 2022 - ncbi.nlm.nih.gov
OBJECTIVE: A substantial number of patients with coronavirus disease-2019 (COVID-19)
demonstrate severe infection. Cytokine storm is an underlying condition that worsens clinical …

tocilizumab in the treatment of systemic inflammatory response in a patient with CoVID-19 (clinical case)

DD Avdoshina, AG Dyachkov, DA Gusev - Journal Infectology, 2020 - journal.niidi.ru
tocilizumab in the treatment of systemic inflammatory response in a patient with CoVID-19 (clinical
case) | Avdoshina | Journal Infectology Journal Infectology Žurnal infektologii eng | рус User …

[HTML][HTML] Matched cohort study on the efficacy of tocilizumab in patients with COVID-19

A Rodríguez-Molinero, C Pérez-López… - One Health, 2021 - Elsevier
Background Tocilizumab has been proposed as a treatment for the new disease COVID-19,
however, there is not enough scientific evidence to support this treatment. The objective of …

Tocilizumab for treatment of severe COVID-19 patients: preliminary results from SMAtteo COvid19 REgistry (SMACORE)

M Colaneri, L Bogliolo, P Valsecchi, P Sacchi… - Microorganisms, 2020 - mdpi.com
Objective: This study aimed to assess the role of Tocilizumab therapy (TCZ) in terms of ICU
admission and mortality rate of critically ill patients with severe COVID-19 pneumonia …

Highlights of clinical and laboratory parameters among severe COVID-19 patients treated with tocilizumab: a retrospective observational study

MU Şener, T Çiçek, A Öztürk - Sao Paulo Medical Journal, 2022 - SciELO Brasil
ABSTRACT BACKGROUND: Coronavirus disease 2019 (COVID-19) can cause cytokine
release syndrome (CRS), which leads to high mortality rates. Tocilizumab suppresses CRS …

COVIDOSE: a phase II clinical trial of low‐dose tocilizumab in the treatment of noncritical COVID‐19 pneumonia

GW Strohbehn, BL Heiss, SJ Rouhani… - Clinical …, 2021 - Wiley Online Library
Interleukin‐6 (IL‐6)–mediated hyperinflammation may contribute to the mortality of
coronavirus disease 2019 (COVID‐19). The IL‐6 receptor–blocking monoclonal antibody …

[HTML][HTML] Beneficial of adding tocilizumab to standard care in critical forms of COVID-19 pneumonia: study on paired series

A Trif, C Abdennebi, A Mehdi, KB Romdhane… - La Tunisie …, 2022 - ncbi.nlm.nih.gov
Abstract Introduction: Tocilizumab (TCZ), a humanized monoclonal antibody directed
against interleukin-6 (IL-6) receptors, has been tried in various studies as a Covid-19 …

Experience of using tocilizumab for treatment in Indonesian patients with severe COVID-19

A Widysanto, A Kurniawan, NPH Lugito, M Yuniarti… - Cytokine, 2021 - Elsevier
COVID-19 is a public health emergency of international concern with millions confirmed
cases globally including in Indonesia with more than two hundred thousand confirmed …

Tocilizumab in hospitalized patients with severe Covid-19 pneumonia

IO Rosas, N Bräu, M Waters, RC Go… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background Coronavirus disease 2019 (Covid-19) is associated with immune
dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of …