Studies have shown significant cardiovascular effects of exogenous apelin administration,
including the potent activation of cardiac contraction. However, the role of the endogenous …

Background Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an
important regulator of the cardiovascular homoeostasis. We previously demonstrated that …

Apelin interacts with the APJ receptor to enhance inotropy. In heart failure, apelin-APJ
coupling may provide a means of enhancing myocardial function. The alterations in apelin …

Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a
potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …

The G protein-coupled apelin receptor regulates important processes of the cardiovascular
homeostasis, including cardiac development, cardiac contractility, and vascular tone. Most …

Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor,
APJ. This novel peptidic signalling pathway is widely represented in the heart and …

Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, is emerging as a key
hormone in cardiovascular homoeostasis. It is expressed in a diverse range of tissues with …

Background—Apelin is among the most potent stimulators of cardiac contractility known.
However, no physiological or pathological role for apelin–angiotensin receptor-like 1 (APJ) …

The apelin/apelin receptor system is widely distributed and has a dominant role in
cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as …

Objective: The endogenous peptide apelin is differentially regulated in cardiovascular
disease but the nature of its role in cardiac function remains unclear. Methods: We …