We have created a transgenic mouse with tissue-specific expression of the human
papilloma virus (HPV) 16 E6 and E7 oncoproteins in the thyroid as a model of HPV …

We have shown that Listeria-based cancer vaccines inhibit the growth of transplanted
tumors in a transgenic mouse model of immune tolerance where HPV-16 E7 is expressed in …

Previous work in our laboratory has established that the fusion of tumor-associated antigens
to a truncated form of the Listeria monocytogenes virulence factor listeriolysin O (LLO) …

Listeria monocytogenes, a facultative intracellular bacterium, can induce a potent antitumor
immune response if engineered to express a model tumor antigen also expressed by the …

Two recombinant Listeria monocytogenes (rLm) strains were produced that secrete the
human papilloma virus-16 (HPV-16) E7 protein expressed in HPV-16-associated cervical …

The facultative intracellular bacterium Listeria monocytogenes is being developed as a
cancer vaccine platform because of its ability to induce potent innate and adaptive immunity …

Cancer receives enduring international attention due to its extremely high morbidity and
mortality. Immunotherapy, which is generally expected to overcome the limits of traditional …

Listeria monocytogenes, a Gram-positive facultative anaerobic bacterium, is becoming a
popular vector for cancer immunotherapy. Indeed, multiple vaccines have been developed …

The bacterium L. monocytogenes is a proposed vaccine carrier based upon the observation
that this pathogen replicates within the intracytoplasmic environment facilitating delivery of …

Abstract Purpose of Review Immunotherapy has emerged as a promising cancer treatment;
however, success in only select clinical indications underscores the need for novel …