Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand

SA Kularatne, K Wang, HKR Santhapuram… - Molecular …, 2009 - ACS Publications
Prostate cancer (PCa) is a major cause of mortality and morbidity in Western society today.
Current methods for detecting PCa are limited, leaving most early malignancies …

Cell‐Surface labeling and internalization by a fluorescent inhibitor of prostate‐specific membrane antigen

T Liu, LY Wu, M Kazak, CE Berkman - The Prostate, 2008 - Wiley Online Library
BACKROUND Prostate‐specific membrane antigen (PSMA) remains an attractive target for
imaging and therapeutic applications for prostate cancer. Recent efforts have been made to …

Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: In vivo Imaging in Experimental Models of Prostate Cancer

CA Foss, RC Mease, H Fan, Y Wang, HT Ravert… - Clinical cancer …, 2005 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) is a cell surface protein that is
overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our …

PSMA-targeting imaging and theranostic agents—Current status and future perspective

S Debnath, N Zhou, M McLaughlin, S Rice… - International journal of …, 2022 - mdpi.com
In the past two decades, extensive efforts have been made to develop agents targeting
prostate-specific membrane antigen (PSMA) for prostate cancer imaging and therapy. To …

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer

SM Hillier, KP Maresca, G Lu, RD Merkin… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and
small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent …

Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted 99mTc-Radioimaging Agents

SA Kularatne, Z Zhou, J Yang, CB Post… - Molecular …, 2009 - ACS Publications
The high mortality and financial burden associated with prostate cancer can be partly
attributed to a lack of sensitive screening methods for detection and staging of the disease …

[HTML][HTML] Towards personalized treatment of prostate cancer: PSMA I&T, a promising prostate-specific membrane antigen-targeted theranostic agent

KLS Chatalic, S Heskamp, M Konijnenberg… - Theranostics, 2016 - ncbi.nlm.nih.gov
Prostate-specific membrane antigen (PSMA) is a well-established target for nuclear imaging
and therapy of prostate cancer (PCa). Radiolabeled small-molecule PSMA inhibitors are …

Improving the biodistribution of PSMA‐targeting tracers with a highly negatively charged linker

SS Huang, X Wang, Y Zhang, A Doke… - The …, 2014 - Wiley Online Library
BACKGROUND Prostate specific membrane antigen (PSMA) is overexpressed in prostate
cancer and in tumor vasculature. Small molecule based inhibitors of PSMA have promised …

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with …

S Vallabhajosula, A Nikolopoulou… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a well-established target for developing
radiopharmaceuticals for imaging and therapy of prostate cancer (PCa). We have recently …

Small-molecule PSMA ligands. Current state, SAR and perspectives

AE Machulkin, YA Ivanenkov… - Journal of drug …, 2016 - Taylor & Francis
Prostate cancer (PC) is the prevalent malignancy widespread among men in the Western
World. Prostate specific membrane antigen (PSMA) is an established PC marker and has …