Extracellular vesicle identification using label-free surface-enhanced raman spectroscopy: detection and signal analysis strategies

H Shin, D Seo, Y Choi - Molecules, 2020 - mdpi.com
Extracellular vesicles (EVs) have been widely investigated as promising biomarkers for the
liquid biopsy of diseases, owing to their countless roles in biological systems. Furthermore …

Recent progress in surface-enhanced Raman spectroscopy-based biosensors for the detection of extracellular vesicles

H Zheng, Q Ding, C Li, W Chen, X Chen, Q Lin… - Analytical …, 2022 - pubs.rsc.org
Extracellular vesicles (EVs) are a type of mediator that enables intercellular communication.
Moreover, EVs carry critical molecular information from parental cells, making them ideal …

Plasmonic sensors for extracellular vesicle analysis: From scientific development to translational research

LK Chin, T Son, JS Hong, AQ Liu, J Skog, CM Castro… - Acs Nano, 2020 - ACS Publications
Extracellular vesicles (EVs), actively shed from a variety of neoplastic and host cells, are
abundant in blood and carry molecular markers from parental cells. For these reasons, EVs …

An integrated sample-to-answer SERS platform for multiplex phenotyping of extracellular vesicles

W Lin, L Yuan, Z Gao, G Cai, C Liang, M Fan… - Sensors and Actuators B …, 2023 - Elsevier
Tumor-derived extracellular vesicles (EVs) are emerging as a non-invasive liquid biopsy
marker for cancer diagnosis and treatment monitoring. However, clinical detection …

Surface-enhanced Raman scattering (SERS) spectroscopy for sensing and characterization of exosomes in cancer diagnosis

L Guerrini, E Garcia-Rico, A O'Loghlen, V Giannini… - Cancers, 2021 - mdpi.com
Simple Summary The distinct molecular and biological properties of exosomes, together
with their abundance and stability, make them an ideal target in liquid biopsies for early …

Enabling sensitive phenotypic profiling of cancer-derived small extracellular vesicles using surface-enhanced Raman spectroscopy nanotags

W Zhang, L Jiang, RJ Diefenbach, DH Campbell… - ACS …, 2020 - ACS Publications
Circulating cancer-derived small extracellular vesicles (EVs) are nanoscale membranous
vesicles shed from cancer cells that are released into surrounding body fluids. Small EVs …

Advances in the application of exosomes identification using surface-enhanced Raman spectroscopy for the early detection of cancers

L Yang, J Jia, S Li - Frontiers in Bioengineering and Biotechnology, 2022 - frontiersin.org
Exosomes are small nanoscale vesicles with a double-layered lipid membrane structure
secreted by cells, and almost all types of cells can secrete exosomes. Exosomes carry a …

Surface-enhanced Raman spectroscopy as a tool for distinguishing extracellular vesicles under autophagic conditions: a marker for disease diagnostics

D Chalapathi, S Padmanabhan… - The Journal of …, 2020 - ACS Publications
Extracellular vesicles (EVs) laden with lipids, proteins, DNA, and micro-RNAs play important
biological functions in intercellular communication and have pivotal roles in …

Identification of individual exosome‐like vesicles by surface enhanced raman spectroscopy

S Stremersch, M Marro, BE Pinchasik, P Baatsen… - Small, 2016 - Wiley Online Library
Exosome‐like vesicles (ELVs) are a novel class of biomarkers that are receiving a lot of
attention for the detection of cancer at an early stage. In this study the feasibility of using a …

Characterization and visualization of vesicles in the endo-lysosomal pathway with surface-enhanced Raman spectroscopy and chemometrics

A Huefner, WL Kuan, KH Müller, JN Skepper… - ACS …, 2016 - ACS Publications
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive vibrational
fingerprinting technique widely used in analytical and biosensing applications. For …