NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) inflammasome has recently
become an intriguing target of several chronic and viral diseases. Here, we argue that …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Following entry and replication of Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-
CoV-2) into ACE2 expressing cells, the infected cells undergo lysis releasing more virus but …

Novel coronaviruses (nCoVs) encode ion-channel proteins called viroporins such as protein
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …

The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases …

Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by respiratory
failure, shock or multiorgan dysfunction, often accompanied by systemic hyperinflammation …

A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

Background Coronavirus-associated acute respiratory distress syndrome (CARDS) has
limited effective therapy to date. NLRP3 inflammasome activation induced by SARS-CoV-2 …

NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …