[HTML][HTML] Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis

H Pan, L Lu, J Cui, Y Yang, Z Wang, X Fan - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Uveal melanoma is an aggressive intraocular malignancy that often exhibits low
immunogenicity. Metastatic uveal melanoma samples frequently exhibit monosomy 3 or …

[HTML][HTML] Molecular profiling of driver events in metastatic uveal melanoma

J Karlsson, LM Nilsson, S Mitra, S Alsén… - Nature …, 2020 - nature.com
Metastatic uveal melanoma is less well understood than its primary counterpart, has a
distinct biology compared to skin melanoma, and lacks effective treatments. Here we …

Single-Cell RNA Sequencing and AlphaFold 3 Insights into Cytokine Signaling and Its Role in Uveal melanoma

HY Sun, C Li, Z Pu, Y Lu, Z Wu, L Zhou, H Lin… - Frontiers in …, 2025 - frontiersin.org
Background: Uveal melanoma (UVM) is a form of eye cancer with a poor prognosis,
particularly in metastatic patients. This study aimed to elucidate the cellular heterogeneity …

Single-cell and bulk transcriptome analysis reveals tumor cell heterogeneity and underlying molecular program in uveal melanoma

K Li, J Huang, Y Tan, J Sun, M Zhou - Journal of Translational Medicine, 2024 - Springer
Background Uveal melanoma (UM) is a rare and deadly eye cancer with high metastatic
potential. Despite the predominance of malignant cells within the tumor microenvironment …

Single-cell RNA sequencing reveals key molecular drivers and immune landscape in uveal melanoma: implications for targeted therapy and prognostic modeling

Z Song, W Shao, Z Xiahou, Y Xu, X Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Background Uveal melanoma (UM), arising from melanocytes in the choroid, accounts for
3% to 5% of all melanocytic tumors and over 70% of intraocular malignancies. Despite …

Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

S Sun, B Guo, L Xu, R Shi - BMC cancer, 2022 - Springer
Background Uveal melanoma (UM) is the most common primary intraocular malignancy with
a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The …

Transcriptome profiling reveals new insights into the immune microenvironment and upregulation of novel biomarkers in metastatic uveal melanoma

Y Krishna, A Acha-Sagredo, D Sabat-Pośpiech… - Cancers, 2020 - mdpi.com
Simple Summary Uveal melanoma (UM) is a rare aggressive eye cancer. Although
treatment of the eye tumour is successful, about 50% of UM patients develop a relapse of …

Identification of a prognostic six-immune-gene signature and a nomogram model for uveal melanoma

B Yang, Y Fan, R Liang, Y Wu, A Gu - BMC ophthalmology, 2023 - Springer
Background To identify an immune-related prognostic signature and find potential
therapeutic targets for uveal melanoma. Methods The RNA-sequencing data obtained from …

Machine learning and single-cell RNA sequencing reveal relationship between intratumor CD8+ T cells and uveal melanoma metastasis

S Chen, Z Tang, Q Wan, W Huang, X Li, X Huang… - Cancer Cell …, 2024 - Springer
Purpose Uveal melanoma (UM) is adults' most common primary intraocular malignant tumor.
It has been observed that 40% of patients experience distant metastasis during subsequent …

Bioinformatic Analysis Reveals Central Role for Tumor‐Infiltrating Immune Cells in Uveal Melanoma Progression

M Lachota, A Lennikov, KJ Malmberg… - Journal of …, 2021 - Wiley Online Library
Tumor‐infiltrating immune cells are capable of effective cancer surveillance, and their
abundance is linked to better prognosis in numerous tumor types. However, in uveal …