A new group of phage anti-CRISPR genes inhibits the type IE CRISPR-Cas system of Pseudomonas aeruginosa
A Pawluk, J Bondy-Denomy, VHW Cheung… - MBio, 2014 - Am Soc Microbiol
ABSTRACT CRISPR-Cas systems are one of the most widespread phage resistance
mechanisms in prokaryotes. Our lab recently identified the first examples of phage-borne …
mechanisms in prokaryotes. Our lab recently identified the first examples of phage-borne …
Disabling a type IE CRISPR-Cas nuclease with a bacteriophage-encoded anti-CRISPR protein
ABSTRACT CRISPR (clustered regularly interspaced short palindromic repeat)-Cas
adaptive immune systems are prevalent defense mechanisms in bacteria and archaea. They …
adaptive immune systems are prevalent defense mechanisms in bacteria and archaea. They …
The CRISPR/Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phages
KC Cady, J Bondy-Denomy, GE Heussler… - Journal of …, 2012 - Am Soc Microbiol
Here we report the isolation of 6 temperate bacteriophages (phages) that are prevented from
replicating within the laboratory strain Pseudomonas aeruginosa PA14 by the endogenous …
replicating within the laboratory strain Pseudomonas aeruginosa PA14 by the endogenous …
Non-identity-mediated CRISPR-bacteriophage interaction mediated via the Csy and Cas3 proteins
KC Cady, GA O'Toole - Journal of bacteriology, 2011 - Am Soc Microbiol
ABSTRACT Studies of the Escherichia, Neisseria, Thermotoga, and Mycobacteria c lustered
r egularly i nterspaced s hort p alindromic r epeat (CRISPR) subtypes have resulted in a …
r egularly i nterspaced s hort p alindromic r epeat (CRISPR) subtypes have resulted in a …
Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species
A Pawluk, RHJ Staals, C Taylor, BNJ Watson… - Nature …, 2016 - nature.com
CRISPR-Cas systems provide sequence-specific adaptive immunity against foreign nucleic
acids 1, 2. They are present in approximately half of all sequenced prokaryotes 3 and are …
acids 1, 2. They are present in approximately half of all sequenced prokaryotes 3 and are …
CRISPR-Cas systems restrict horizontal gene transfer in Pseudomonas aeruginosa
RM Wheatley, RC MacLean - The ISME journal, 2021 - academic.oup.com
CRISPR-Cas systems provide bacteria and archaea with an adaptive immune system that
targets foreign DNA. However, the xenogenic nature of immunity provided by CRISPR-Cas …
targets foreign DNA. However, the xenogenic nature of immunity provided by CRISPR-Cas …
Keeping crispr in check: diverse mechanisms of phage-encoded anti-crisprs
D Trasanidou, AS Geros, P Mohanraju… - FEMS microbiology …, 2019 - academic.oup.com
ABSTRACT CRISPR-Cas represents the only adaptive immune system of prokaryotes
known to date. These immune systems are widespread among bacteria and archaea, and …
known to date. These immune systems are widespread among bacteria and archaea, and …
Phage-encoded anti-CRISPR defenses
SY Stanley, KL Maxwell - Annual review of genetics, 2018 - annualreviews.org
The battle for survival between bacteria and bacteriophages (phages) is an arms race where
bacteria develop defenses to protect themselves from phages and phages evolve …
bacteria develop defenses to protect themselves from phages and phages evolve …
Mobile element warfare via CRISPR and anti-CRISPR in Pseudomonas aeruginosa
Bacteria deploy multiple defenses to prevent mobile genetic element (MGEs) invasion.
CRISPR–Cas immune systems use RNA-guided nucleases to target MGEs, which counter …
CRISPR–Cas immune systems use RNA-guided nucleases to target MGEs, which counter …
Phylogenetic distribution of CRISPR-Cas systems in antibiotic-resistant Pseudomonas aeruginosa
Pseudomonas aeruginosa is an antibiotic-refractory pathogen with a large genome and
extensive genotypic diversity. Historically, P. aeruginosa has been a major model system for …
extensive genotypic diversity. Historically, P. aeruginosa has been a major model system for …