Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of
Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Thoracic aortic aneurysms (TAA) are permanent and localized dilations of the aorta that
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …

Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Aims Human thoracic aortic aneurysms (TAAs) are characterized by extracellular matrix
breakdown associated with progressive smooth muscle cell (SMC) rarefaction. These …

Thoracic aortic aneurysms leading to type A dissections (TAAD) can be inherited in isolation
or in association with genetic syndromes, such as Marfan syndrome and Loeys-Dietz …

BACKGROUND: Knowledge in the aetiopathogeny of aortic disease helps to characterise
aortic lesions better and determine the risk of evolution and therapeutic strategies as well …

Objective—Recent studies suggested the occurrence of phenotypic switching of vascular
smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However …

Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Aortic aneurysms are responsible for a significant number of all deaths in Western countries.
In this review we provide a perspective on the important progress made over the past …