AP-1 transcriptional activity is stimulated by the transformation promoters phorbol 12-
myristate 13-acetate (" 12-O-tetradecanoylphorbol 13-acetate," TPA) and epidermal growth …

Tumor promoters may bring about events that lead to neoplastic transformation by inducing
specific promotion-relevant effector genes. Functional activation of the transacting …

The JB6 mouse epidermal cell system, which includes tumor promotion-sensitive (P+) and
tumor promotion-resistant (P−) cells, is a well-established and extensively used cell culture …

AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation
induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …

The present study was directed to characterizing the reversion of neoplastic epidermal JB6
RT101 cells by AP-1 inhibiting drugs. Treatment of tumorigenic JB6 RT101 cells with retinoic …

Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun
homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter …

Transcription factor activator protein 1 (AP1) interacts with the promoter region of a number
of genes that are stimulated by growth factors present in serum or by agents such as phorbol …

Both retinoic acid (RA) treatment and dominant-negative c-Jun mutant expression effectively
inhibit phorbol ester-induced AP-1 activity and induced neoplastic transformation in mouse …

Mitogen-activated protein (MAP) kinase, extracellular-signal-regulated kinases (ERKs) play
an important role in activating AP-1-dependent transcription. Studies using the JB6 mouse …

The conversion of cultured basal keratinocytes to the spinous and granular cell phenotypes
seen in the skin can be stimulated by raising the levels of extracellular calcium. Here we …