CONDOR: a database resource of developmentally associated conserved non-coding elements
Background Comparative genomics is currently one of the most popular approaches to
study the regulatory architecture of vertebrate genomes. Fish-mammal genomic …
study the regulatory architecture of vertebrate genomes. Fish-mammal genomic …
Ancient duplicated conserved noncoding elements in vertebrates: a genomic and functional analysis
Fish–mammal genomic comparisons have proved powerful in identifying conserved
noncoding elements likely to be cis-regulatory in nature, and the majority of those tested in …
noncoding elements likely to be cis-regulatory in nature, and the majority of those tested in …
The importance of being cis: evolution of orthologous fish and mammalian enhancer activity
Conserved noncoding elements (CNEs) in vertebrate genomes often act as developmental
enhancers, but a critical issue is how well orthologous CNE sequences retain the same …
enhancers, but a critical issue is how well orthologous CNE sequences retain the same …
Organization of conserved elements near key developmental regulators in vertebrate genomes
Sequence conservation has traditionally been used as a means to target functional regions
of complex genomes. In addition to its use in identifying coding regions of genes, the recent …
of complex genomes. In addition to its use in identifying coding regions of genes, the recent …
[HTML][HTML] Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes
Pan-vertebrate developmental cis-regulatory elements are discernible as highly conserved
noncoding elements (HCNEs) and are often dispersed over large areas around the …
noncoding elements (HCNEs) and are often dispersed over large areas around the …
Early evolution of conserved regulatory sequences associated with development in vertebrates
Comparisons between diverse vertebrate genomes have uncovered thousands of highly
conserved non-coding sequences, an increasing number of which have been shown to …
conserved non-coding sequences, an increasing number of which have been shown to …
Tuning in to the signals: noncoding sequence conservation in vertebrate genomes
Aligning and comparing genomic sequences enables the identification of conserved
sequence signatures and can enrich for coding and noncoding functional regions. In …
sequence signatures and can enrich for coding and noncoding functional regions. In …
Exploiting human–fish genome comparisons for deciphering gene regulation
Comparative genomics has served as an essential guide in the identification of functional
coding and non-coding sequences in vertebrate genomes. Human–mouse pair-wise …
coding and non-coding sequences in vertebrate genomes. Human–mouse pair-wise …
Highly conserved non-coding sequences are associated with vertebrate development
In addition to protein coding sequence, the human genome contains a significant amount of
regulatory DNA, the identification of which is proving somewhat recalcitrant to both in silico …
regulatory DNA, the identification of which is proving somewhat recalcitrant to both in silico …
Shuffling of cis-regulatory elements is a pervasive feature of the vertebrate lineage
R Sanges, E Kalmar, P Claudiani, M D'Amato, F Muller… - Genome biology, 2006 - Springer
Background All vertebrates share a remarkable degree of similarity in their development as
well as in the basic functions of their cells. Despite this, attempts at unearthing genome-wide …
well as in the basic functions of their cells. Despite this, attempts at unearthing genome-wide …